1
Paul R Meers, Charles Pak, Shaukat Ali, Andrew Janoff, J Craig Franklin, Ravi K Erukulla, Donna Cabral Lilly: Peptide-lipid conjugates. The Liposome Company, Rosanne Goodman, July 11, 2000: US06087325 (52 worldwide citation)

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat ma ...


2
Paul R Meers, Charles Pak, Shaukat Ali, Andrew Janoff, J Craig Franklin, Ravi K Erukulla, Donna Cabral Lilly, Patrick L Ahl: Peptide-lipid conjugates, liposomes and lipsomal drug delivery. Elan PharmaceuticalsTechnologies, Burns Doane Swecker & Mathis L, January 15, 2002: US06339069 (41 worldwide citation)

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat ma ...


3
Paul R Meers, Tong Shangguan, Shaukat Ali, Andrew Janoff, Charles Pak: N-acyl phosphatidylethanolamine-mediated liposomal drug delivery. The Liposome Company, Rosanne Goodman, September 25, 2001: US06294191 (22 worldwide citation)

This invention provides liposomes containing one or more N-acylated phosphatidylethanolamines, such liposomes being useful for localizing the delivery of bioactive agents to cells.


4
Paul R Meers, Tong Shangguan, Shaukat Ali, Andrew Janoff, Charles Pak: N-acyl phosphatidylethanolamine-mediated liposomal drug delivery. The Liposome Company, Rosanne Goodman, September 19, 2000: US06120797 (17 worldwide citation)

This invention provides liposomes containing one or more N-acylated phosphatidylethanolamines, such liposomes being useful for localizing the delivery of bioactive agents to cells.


5
Walter Perkins, Xingong Li, Donald Hirsh, Eric Mayhew, Imran Ahmad, Shaukat Ali, Andrew Janoff: Particulate formulations. The Liposome Company, Burns Doane Swecker & Mathis L, December 31, 2002: US06500461 (14 worldwide citation)

This invention provides vehicles capable of delivering high concentrations of poorly hydrophilic/poorly lipophilic compounds to animals, by combining compounds having biocompatible hydrophobic domains with conjugates having both hydrophobic and hydrophilic regions. Such formulations are suitable for ...


6
Shaukat Ali, J Craig Franklin, Imran Ahmad, Eric Mayhew, Soumendu Bhattacharya, Gil Koehane, Andrew S Janoff: Hydrolysis-promoting hydrophobic taxane derivatives. The Liposome Company, Burns Doane Swecker & Mathis L, November 19, 2002: US06482850 (8 worldwide citation)

Provided herein is a taxane having a hydrocarbon attached at the 2′ and/or 7 positions, the hydrocarbon's alpha position being occupied by a “hydrolysis-promoting group” (“HPG”). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the &agr;-carbon of the hydropho ...


7
Paul R Meers, Charles Pak, Shaukat Ali, Andrew Janoff, J Craig Franklin, Ravi K Erukulla, Donna Cabral Lilly: Liposomal peptide-lipid conjugates and delivery using same. The Liposome Company, Rosanne Goodman, November 7, 2000: US06143716 (8 worldwide citation)

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat ma ...


8
Eric Mayhew, Shaukat Ali, Andrew S Janoff: Hydrolysis-promoting hydrophobic taxane derivatives. The Liposome Company, Kenneth B Rubin, December 30, 1997: US05703117 (3 worldwide citation)

Provided herein is a taxane having a hydrocarbon attached at the 2' and/or 7 positions, the hydrocarbon's alpha position being occupied by a "hydrolysis-promoting group" ("HPG"). Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydroly ...


9
Shaukat Ali, J Craig Franklin, Imran Ahmad, Eric Mayhew, Soumendu Bhattacharya, Gil Koehane, Andrew S Janoff: Hydrolysis-promoting hydrophobic taxane derivatives. The Liposome Company, Rosanne Goodman, August 22, 2000: US06107332 (2 worldwide citation)

Provided herein is a taxane having a hydrocarbon attached at the 2' and/or 7 positions, the hydrocarbon's alpha position being occupied by a "hydrolysis-promoting group" ("HPG"). In one embodiment, the hydrolysis promoting group is stereospecifically attached to the .alpha.-carbon of the hydrophobic ...


10
Eric Mayhew, Shaukat Ali, Andrew S Janoff: Liposomal hydrolysis-promoting hydrophobic taxane derivatives. April 18, 2000: US06051600 (1 worldwide citation)

Provided herein is a taxane having a hydrocarbon attached at the 2' and/or 7 positions, the hydrocarbon's alpha position being occupied by a "hydrolysis-promoting group" ("HPG"). Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydroly ...