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Merouane Bencherif, Nikolai Fedorov, Terry Hauser, Kristen Jordan, Sharon Rae Letchworth, Anatoly Mazurov, Julio A Munoz, Jason Speake, Daniel Yohannes: Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]OCT-3-yl)-3,5-difluorobenzamide. Targacept, Amy H Fix, July 2, 2013: US08476296 (2 worldwide citation)

The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety ...


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Merouane Bencherif, Nikolai Fedorov, Terry Hauser, Kristen Jordan, Sharon Rae Letchworth, Anatoly Mazurov, Julio A Munoz, Jason Speake, Daniel Yohannes: Preparation and therapeutic applications of (2S, 3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]OCT-3-yl)-3,5-difluorobenzamide. Targacept, Amy H Fix, Womble Carlyle Sandridge & Rice, December 2, 2014: US08901151 (1 worldwide citation)

The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety ...


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Merouane Bencherif, Nikolai Federov, Terry Hauser, Kristen G Jordan, Sharon Rae Letchworth, Anatoly Mazurov, Julio A Munoz, Jason Speake, Daniel Yohannes: Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide. BRINKS GILSON & LIONE, November 3, 2015: US09173876

The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety ...


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Merouane Bencherif, Ronald J Lukas, Sharon Rae Letchworth, Vladimir Grinevich: Composition and pharmacology of novel alpha6-containing nicotinic acetylcholine receptors. Womble Carlyle Sandridge & Rice Pllc, March 12, 2009: US20090068642-A1

Nicotinic acetylcholine receptors (nAChRs) comprising the α6 receptor subunit; nucleic acids, including vectors, comprising subunit incoding sequences; cells expressing the nAChRs of the invention; and methods of screening compounds are provided.


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Sharon Rae Letchworth, Merouane Bencherif, Gary Maurice Dull, David Moore, John W James: Intranasal, Buccal, And Sublingual Administration Of Metanicotine Analogs. Targacept, Pepper Hamilton, February 4, 2010: US20100028447-A1

The present invention generally relates to pharmaceutical compositions for the intranasal, buccal, or sublingual administration of metanicotine analogs.


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Kristen G Jordan, Sharon Rae Letchworth, Merouane Bencherif: Reversal of l-dopa-induced dyskinesia by neuronal nicotinic receptor ligands. Targacept, June 21, 2012: US20120157477-A1

The present invention includes methods, uses, and compounds for treating or preventing L-dopa-induced dyskinesias.


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Merouane Bencherif, Kristen Jordan, Terry Hauser, Steven M Toler, Sharon Rae Letchworth, David C Kombo: Treatment with alpha7 selective ligands. Targacept, October 27, 2011: US20110262407-A1

The present invention includes methods, uses, and selective alpha7 nAChR ligands for treating or preventing disease and disorders in which stimulation of neurogenesis is ameliorative; namely, wherein the recruitment of neurogenesis is therapeutic.


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Merouane Bencherif, Nikolai Fedorov, Terry Hauser, Kristen Jordan, Sharon Rae Letchworth, Anatoly Mazurov, Julio A Munoz, Jason Speake, Daniel Yohannes: Preparation and therapeutic applications of (2s,3r)-n-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide. Targacept, October 20, 2011: US20110257224-A1

The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetyl-choline receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety ...


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