1
Yoshiro Niitsu, Victor Knopov, Joseph E Payne, Richard P Witte, Mohammad Ahmadian, Loren A Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu: Retinoid-liposomes for treating fibrosis. Nitto Denko Corporation, Baker & Hostetler, June 3, 2014: US08741867 (7 worldwide citation)

What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPINH1_45a (SEQ ID ...


2
Yoshiro Niitsu, Victor Knopov, Joseph E Payne, Richard P Witte, Mohammad Ahmadian, Loren A Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu: Retinoid-liposomes for enhancing modulation of HSP47 expression. Nitto Denko Corporation, Baker & Hostetler, March 4, 2014: US08664376 (6 worldwide citation)

What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1—2 (SEQ ID NOS: 60 and 127), SERPINH1—45a (SEQ ID ...


3
Yoshiro Niitsu, Victor Knopov, Joseph E Payne, Richard P Witte, Mohammad Ahmadian, Loren A Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu: Method for treating fibrosis using siRNA and a retinoid-lipid drug carrier. Nitto Denko Corporation, Baker & Hostetler, October 4, 2016: US09456984 (4 worldwide citation)

What is described is a method for treating a fibrotic disease by administering a pharmaceutical composition comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.


4
Yoshiro Niitsu, Victor Knopov, Joseph E Payne, Richard P Witte, Mohammad Ahmadian, Loren A Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu, Zheng Hou, John A Gaudette, Priya Karmali, Sridhar C Nagarajan: Retinoid-lipid drug carrier. Nitto Denko Corporation, Baker & Hostetler, February 5, 2019: US10196637

What is described is a pharmaceutical composition for treating a fibrotic disease comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.


5
Yoshiro Niitsu, Victor Knopov, Joseph E Payne, Richard P Witte, Mohammad Ahmadian, Loren A Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu: Method for treating fibrosis using siRNA and a retinoid-lipid drug carrier. Nitto Denko Corporation, Baker & Hostetler, February 5, 2019: US10195145

What is described is a method for treating a fibrotic disease by administering a pharmaceutical composition comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.