1
Robert J Nelson, Herbert H Hooper, Alan K Hauser, Sharat Singh, Stephen J Williams, Alexander P Sassi: Microfluidic method for nucleic acid purification and processing. ACLARA Biosciences, Bertram I Rae Venter Law Group P C Rowland, June 13, 2000: US06074827 (251 worldwide citation)

Integrated microfluidic devices comprising at least an enrichment channel and a main electrophoretic flowpath are provided. In the subject integrated devices, the enrichment channel and the main electrophoretic flowpath are positioned so that waste fluid flows away from said main electrophoretic flo ...


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Ann K Wainright, Irene Visser, Sharat Singh: Methods and compositions for conducting processes in microfluidic devices. Aclara BioSciences, Perkins Coie, October 23, 2001: US06306273 (111 worldwide citation)

A method is disclosed for controlling the direction and transport of a material on a microfluidic device formed from an acrylic polymer, by electrokinetic flow of a fluid containing the material. The method comprises providing an electrokinesis buffer containing a charged hydrophilic polymer, wherei ...


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Edwin F Ullman, Sharat Singh, Ian Gibbons, Travis Boone, Torlief Bjornson: Sample evaporative control. Aclara BioSciences, Peter J Dehlinger, Perkins Coie, April 29, 2003: US06555389 (72 worldwide citation)

Devices and methods are provided using microfluidic devices for manipulating small volumes and determining a variety of chemical and physical events. The devices rely upon an opening to the atmosphere of a small volume in a zone, where a sample is placed in the zone where evaporation can occur. The ...


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Sharat Singh, Vivian Xiao, Ian Gibbons, Travis Boone, Torleif Ove Bjornson, Herbert H Hooper, Edwin F Ullman: Sample evaporative control. Aclara BioSciences, Peter J Dehlinger, Jacqueline F Mahoney, Perkins Coie, September 30, 2003: US06627406 (56 worldwide citation)

Devices and methods are provided using microfluidic devices for manipulating small volumes and determining a variety of chemical and physical events. The devices rely upon an opening to the atmosphere of a small volume in a zone, where a sample is placed in the zone where evaporation can occur. The ...


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Sharat Singh: Single nucleotide detection using degradation of a fluorescent sequence. Aclara Biosciences, November 27, 2001: US06322980 (42 worldwide citation)

Methods and compositions are provided for detecting single nucleotide polymorphisms using a pair of oligonucleotides, a primer and a snp detection sequence, where the snp detection sequence hybridizes to the target DNA downstream from the primer and in the direction of primer extension. The snp dete ...


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Sharat Singh, Edwin F Ullman: Cyclic ether compounds. Behringwerke, Theodore J Leitereg, July 16, 1996: US05536834 (40 worldwide citation)

Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond substituted with two aryl groups, an oxygen at ...


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Sharat Singh, Edwin F Ullman: Metal chelate containing compositions for use in chemiluminescent assays. Behringwerke, Theodore J Leitereg, Janet Kaku, November 26, 1996: US05578498 (39 worldwide citation)

Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond substituted with two aryl groups, an oxygen at ...


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Ali Mukherjeei, Mengxiang Tang, Harprit S Pannu, Po Ying Chan Hui, Sharat Singh: Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy. Monogram BioSciences, Fenwick & West, July 22, 2008: US07402399 (38 worldwide citation)

The invention provides a method for determining the activation status of receptor tyrosine kinase (RTK) pathways in either cell samples or patient samples by measuring receptor dimerization and relative amounts of protein-protein complexes or activated effector proteins that are characteristic of an ...



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