1

2

3

4
Sharada Shenvi Labadie, Clara Jeou Jen Lin, Francisco Xavier Talamas, Robert James Weikert: Heterocyclic antiviral compounds. Roche Palo Alto, Brian L Buckwalter, December 6, 2011: US08071797 (4 worldwide citation)

Compounds having the formula I wherein R1, R2, R3, R4, R5 and X are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.


5
Lars G J Hammarström, Nancy Elisabth Krauss, Sharada Shenvi Labadie, David Bernard Smith, Francisco Xavier Talamas: Synthesis of purine derivatives. Roche Palo Alto, Grant D Green, September 12, 2006: US07105666 (4 worldwide citation)

The present invention provides a method for producing 2-, 6-, 8- and 9-substituted purine compounds from 4,6-dihalo-5-nitro-2-alkyl-pyrimidine compounds in solution or by solid phase techniques. The present process provides for the sequential introduction of amine substituents at the 4- and 6-positi ...


6

7
Ronald Charles Hawley, Sharada Shenvi Labadie, Eric Brian Sjogren, Francisco Xavier Talamas: Aminopyrimidine and aminopyridine anti-inflammation agents. Roche Palo Alto, Grant D Green, January 25, 2005: US06846828 (1 worldwide citation)

Aminopyrimidine and aminopyridine (I) compounds, compositions and methods useful in the treatment of inflammatory, metabolic or malignant conditions, are provided herein.


8
David Michael Goldstein, Sharada Shenvi Labadie, David Mark Rotstein, Eric Brian Sjogren, Francisco Xavier Talamas: Pyrazole derivatives-p38 MAP kinase inhibitors. Syntex, Robert C Hall, December 27, 2005: US06979693

The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.


9
Sharada Shenvi Labadie, Eric Brian Sjogren, Francisco Xavier Talamas: Thienopyridazines as IKK inhibitors. Roche Palo Alto, Grant D Green, November 14, 2006: US07135470

The invention provides compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein: A, Y, Z and R1 are as defined herein. Also provided are compositions comprising, methods of preparing, and methods for using the subject compounds.


10
Ronald Charles Hawley, Sharada Shenvi Labadie, Eric Brian Sjogren, Francisco Xavier Talamas: Aminopyrimidine and aminopyridine anti-inflammation agents. Roche Palo Alto, Grant D Green, January 2, 2007: US07157580

Aminopyrimidine and aminopyridine (I) compounds, compositions and methods useful in the treatment of inflammatory, metabolic or malignant conditions, are provided herein