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James Doherty
Dorn Conrad P, Finke Paul E, Maccoss Malcolm, Doherty James B, Shah Shrenik K, Hagmann William K: New substituted azetidinones as anti-inflammatory and antidegenerative agents.. Merck & Co, April 22, 1992: EP0481671-A1 (40 worldwide citation)

New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. e


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Dorn Conrad P, Hale Jeffrey J, Maccoss Malcolm, Mills Sander G, Ladduwahetty Tamara, Shah Shrenik K: Morpholine and thiomorpholine tachykinin receptor antagonists.. Merck & Co, January 5, 1994: EP0577394-A1 (78 worldwide citation)

Substituted heterocycles of the general structural formula: are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.


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Doherty James B, Finke Paul E, Firestone Raymond A, Hagmann William K, Shah Shrenik K, Thompson Kevan R: New substituted cephalosporin sulfones as antiinflammatory and antidegenerative agents, pharmaceutical compositions containing the same and processes for making them.. Merck & Co, November 7, 1984: EP0124081-A2 (19 worldwide citation)

New substituted cephalosporin sulfones are disclosed having the structural formula: wherein M is, e.g., trifluoromethyl, chloro or fluoro or -COOH; R1 is, e.g., hydrogen, hydroxy, mercapto, substituted oxy, substituted thio, hydrocarbyl or substituted hydrocarbyl group; B is OB1, or NB2B3 wherein B1 ...


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Toupence Richard B, Debenham John S, Goulet Mark T, Madsen Duggan Christina B, Walsh Thomas F, Shah Shrenik K: Substituted furo [2,3-b] pyridine derivatives. Merck & Co, Toupence Richard B, Debenham John S, Goulet Mark T, Madsen Duggan Christina B, Walsh Thomas F, Shah Shrenik K, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, February 12, 2004: WO/2004/012671 (18 worldwide citation)

Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs ...


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Doherty James B, Finke Paul E, Firestone Raymond A, Hagmann William K, Thompson Kevan R, Shah Shrenik K: New substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents.. Merck & Co, May 18, 1988: EP0267723-A2 (15 worldwide citation)

New substituted cephalosporin sulfones with structural formula: are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.


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Davies Philip, Doherty James B, Finke Paul E, Humes John L, Leudke Edward S, Maccoss Malcolm, Mumford Richard A, Shah Shrenik K: Substituted azetidinones useful in the treatment of leukemia. Merck & Co, November 3, 1993: GB2266527-A (12 worldwide citation)

Compounds of formula I and salts thereof, wherein R is C1-6alkyl; R is C1-6alkyl or C1-6alkoxy-C1-6alkyl; and M, X5, X6, X7 and X8 are hydrogen or specific substituents, are useful in the treatment of leukemia.


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Hanlon William A, Mumford Richard A, Humes John L, Maccoss Malcolm, Knight Wilson B, Finke Paul E, Hagmann William K, Shah Shrenik K: Assay for evaluating inhibition of pmn elastase by n-substituted azetidinones.. Merck & Co, March 3, 1993: EP0529719-A1 (10 worldwide citation)

N-substituted azetidinones are a class of inhibitors of human leukocytes elastase which are known to be useful in the treatment of a wide variety of antiinflammatory and antidegenerative diseases. In inhibiting elastase, the therapeutic agents are shown to form a characteristic stable complex with t ...


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Armstrong Helen M, Chang Linda L, Guthikonda Ravindra N, Hagmann William K, Lin Linus S, Shah Shrenik K: Substituted sulfonamides. Merck & Co, Armstrong Helen M, Chang Linda L, Guthikonda Ravindra N, Hagmann William K, Lin Linus S, Shah Shrenik K, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, March 31, 2005: WO/2005/027837 (8 worldwide citation)

The substituted sulfonamides of the invention are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs ...


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Dobbelaar Peter H, Du Wu, Guo Liangqin, Hagmann William K, He Shuwen, Jian Tianying, Liu Jian, Nargund Ravi P, Pasternak Alexander, Shah Shrenik K, Truong Quang T, Ye Zhixiong, Dellureficio James, Bakshi Raman: Beta carboline derivatives as antidiabetic compounds. Merck & Co, Dobbelaar Peter H, Du Wu, Guo Liangqin, Hagmann William K, He Shuwen, Jian Tianying, Liu Jian, Nargund Ravi P, Pasternak Alexander, Shah Shrenik K, Truong Quang T, Ye Zhixiong, Dellureficio James, Bakshi Raman, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, January 22, 2009: WO/2009/011836 (8 worldwide citation)

Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity ...



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