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Blatt Lawrence M, Seiwert Scott, Beigelman Leonid, Kercher Timothy, Kennedy April L, Andrews Steven W: Novel inhibitors of hepatitis c virus replication. Intermune, Array Biopharma, Blatt Lawrence M, Seiwert Scott, Beigelman Leonid, Kercher Timothy, Kennedy April L, Andrews Steven W, MALLON Joseph J, January 10, 2008: WO/2008/005511 (58 worldwide citation)

The embodiments provide compounds of the general Formula (I), as well as compositions, including pharmaceutical compositions, comprising a, subject compound. The embodiments provide compounds of the general Formula (II), as well as compositions, including pharmaceutical compositions, comprising a su ...


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Beigelman Leonid, Seiwert Scott D, Blatt Lawrence M, Andrews Steven, Haas Julia: Compounds and methods for inhibiting hepatitis c viral replication. Intermune, Array Biopharma, Beigelman Leonid, Seiwert Scott D, Blatt Lawrence M, Andrews Steven, Haas Julia, MALLON Joseph J, April 19, 2007: WO/2007/044893 (56 worldwide citation)

Macrocyclic compounds having the structures described herein arc useful for inhibiting replication of the hepatitis C virus (HCV). In preferred embodiments, the compounds are active against both the NS3 protease and the NS3 helicase of HCV. Formulae (I), (II), (III), (IV) and (V).


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Blatt Lawrence M, Pan Lin, Seiwert Scott, Andrews Steven W, Martin Pierre, Schumacher Andreas, Beigelman Leonid, Liu Jyanwei, Condroski Kevin, Jiang Yutong, Kaus Robert, Kennedy April, Kercher Timothy, Lyon Michael, Wang bin: Novel macrocyclic inhibitors of hepatitis c virus replication. Intermune, Array Biopharma, Blatt Lawrence M, Pan Lin, Seiwert Scott, Andrews Steven W, Martin Pierre, Schumacher Andreas, Beigelman Leonid, Liu Jyanwei, Condroski Kevin, Jiang Yutong, Kaus Robert, Kennedy April, Kercher Timothy, Lyon Michael, Wang bin, MALLON Joseph J, November 13, 2008: WO/2008/137779 (56 worldwide citation)

The embodiments provide macrocyclic compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treatin ...


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Andrews Steven W, Seiwert Scott, Beigelman Leonid, Blatt Lawrence, Buckman Brad: Novel peptide inhibitors of hepatitis c virus replication. Intermune, Array Biopharma, Andrews Steven W, Seiwert Scott, Beigelman Leonid, Blatt Lawrence, Buckman Brad, HART Daniel, November 20, 2008: WO/2008/141227 (54 worldwide citation)

The embodiments provide compounds of the general Formula (I), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the general Formula (II), as well as compositions, including pharmaceutical compositions, comprising a sub ...


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BUCKMAN Brad, NICHOLAS John B, SEREBRYANY Vladimir, SEIWERT Scott D: Nouveaux inhibiteurs de la réplication du virus de lhépatite c, Novel inhibitors of hepatitis c virus replication. Intermune, BUCKMAN Brad, NICHOLAS John B, SEREBRYANY Vladimir, SEIWERT Scott D, HART Daniel, November 24, 2011: WO/2011/146401 (36 worldwide citation)

The embodiments provide compounds of the general Formulae (VI), (VII), (VIII), (IX), (X), (XI), (XII), (XIII), (XIV), and (XV) as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treati ...


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Seiwert Scott, Beigelman Leonid, Buckman Brad, Stoycheva Antitsa Dimitrova, Porter Steven B, Bradford Williamson Ziegler, Serebryany Vladimir: Novel macrocyclic inhibitors of hepatitis c virus replication. Intermune, Seiwert Scott, Beigelman Leonid, Buckman Brad, Stoycheva Antitsa Dimitrova, Porter Steven B, Bradford Williamson Ziegler, Serebryany Vladimir, Mallon Joseph J, November 26, 2009: WO/2009/142842 (25 worldwide citation)

The embodiments provide compounds of the general Formulae I, II, EI, IV, V, VI, VII, and X, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection an ...


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BUCKMAN Brad, NICHOLAS John B, SEREBRYANY Vladimir, SEIWERT Scott D: NOUVEAUX INHIBITEURS DE LA RÉPLICATION DU VIRUS DE LHÉPATITE C, NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION. INTERMUNE, BUCKMAN Brad, NICHOLAS John B, SEREBRYANY Vladimir, SEIWERT Scott D, MALLON Joseph J, June 28, 2012: WO/2012/087976 (16 worldwide citation)

The embodiments provide compounds of the general Formulae XV, XVI, XVII and XVIII as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods ...


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Blatt Lawrence M, Seiwert Scott D, Ozes Osman N: Combination therapy for proliferative disorders. Intermune, Blatt Lawrence M, Seiwert Scott D, Ozes Osman N, BORDEN Paula A, December 9, 2004: WO/2004/105684 (16 worldwide citation)

The present invention provides methods of treating proliferative disorders, including angiogenesis-mediated disorders, cancer, and fibrotic disorders. In some embodiments, the methods involve administering a Type II interferon receptor agonist and a Type I interferon receptor agonist. In other embod ...