1
Sehgal Surendra N, Blazekovic Teodora M, Vezina Claude: Rapamycin and process of preparation. Ayerst McKenna and Harrison, December 30, 1975: US3929992 (345 worldwide citation)

Antibiotic rapamycin is producible by culturing Streptomyces hygroscopicus NRRL 5491 in an aqueous nutrient medium. Rapamycin has antifungal properties. Methods for its preparation and use are disclosed.


2
Vezina Claude, Saucier Rene, Sehgal Surendra N: Process for the preparation of antimycin a. American Home Products Corporation, Routh John W, March 4, 1975: US3869346 (2 worldwide citation)

Improved process for the preparation of Antimycin A in which a suitable source of assimilable carbon is added during fermentation together with continuous control of pH at about pH 6.0, and an improved method of extraction is being used.


3
Sehgal Surendra N, Singh Kartar, Vezina Claude: Antibiotic substances and preparation. Ayers McKenna and Harrison, October 7, 1975: US3911112

A new antibiotic complex, complex 484, components 484-A and 484-B thereof and a process for their preparation are disclosed. These antibiotic substances are producible by culturing a microorganism of the species Streptomyces in an aqueous nutrient medium under submerged aerobic fermentation conditio ...


4
Sehgal Surendra N, Vezina Claude: Ravidomycine et procede de preparation, Ravidomycin and process of preparation. Ayerst Mckenna &Amp Harrison, GOWLING LAFLEUR HENDERSON, October 26, 1982: CA1134299

ABSTRACT OF THE DISCLOSURE Ravidomycin is produced by culturing Streptomyces ravidusNRRL ?,?00 in an aqueous nutrient medium. Ravidomycin is useful asan antibacterial and antitumor agent. Methods for its preparation anduse are disclosed.


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Kluepfel Dieter, Sehgal Surendra N, Vezina Claude: Naphthyridinomycines produite par un streptomyces, Naphthyridinomycin antibiotics from streptomyces. Ayerst Mckenna And Harrison, January 23, 1979: CA1046965

Abstract of the Disclosure Naphthyridinomycin complex, a major component thereofcalled naphthyridinomycin A and a minor component thereof callednaphthyridinomycin B are disclosed. These antibiotic substancesexhibit antibacterial activity. The substances are producibleby culturing a microorganism of ...


7
Sehgal Surendra N, Singh Kartar, Vezina Claude: Antibiotiques et mode de preparation, Antibiotic substances and preparation thereof. Ayerst Mckenna And Harrison, January 23, 1979: CA1046966

Abstract of the Disclosure A new antibiotic complex, complex 484, components 484-Aand 484-B thereof and a process for their preparation aredisclosed. These antibiotic substances are producible byculturing a microorganism of the species Streptomyces in anaqueous nutrient medium under submerged aerobi ...


8
Baker Harold A, Sehgal Surendra N, Vezina Claude, Sidorowicz Anne M: Compose de rapamycine injectable, Injectable composition of rapamycin. Ayerst Mckenna &Amp Harrison, GOWLING LAFLEUR HENDERSON, November 6, 1984: CA1177399

AHP-7617 ABSTRACT OF THE DISCLOSUREDescribed is an injectable composition of rapamycin and a nonionicsurfactant selected from polyoxyethylated fatty acids, polyoxyethylated fattyalcohols or polyoxyethylated glycerine hydroxy fatty acid esters and a methodof preparing said compositions. The compositi ...


9
Armstrong Jay J, Sehgal Surendra N: Immunosuppression technique accompanied with medication of lapamycin added tangible blood component. American Home Prod, July 19, 1994: JP1994-199671

PURPOSE: To provide a medicinal compsn. effective for medication into the inside of the vein or artery with lapamycin in order to treat the diseases, syndromes, symptoms or immunological response reacting with the treatment using the lapamycin and a process for producing the same. CONSTITUTION: This ...


10
Caufield Craig E, Musser John H, Sehgal Surendra N: Treatment of immune inflammatory disease. American Home Prod, July 5, 1994: JP1994-183967

PURPOSE: To provide a medicinal compsn. for treatment of the immune inflammatory intestinal diseases of mammals. CONSTITUTION: This medicinal compsn. for treatment of the immune inflammatory intestinal diseases of the mammals consists of lapamycin of an antiimmune inflammation quantity and a medicin ...