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Stephen Thomas Davis, Scott Howard Dickerson, Philip Anthony Harris, Robert Neil Hunter III, Lee Frederick Kuyper, Karen Elizabeth Lackey, Michael Joseph Luzzio, James Marvin Veal, Duncan Herrick Walker: Substituted oxidole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors. SmithKline Beecham Corporation, John L Lemanowicz, April 9, 2002: US06369086 (39 worldwide citation)

The present invention relates generally to novel substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of protein kinase activated signalling pathways. In p ...


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Stephen Thomas Davis, Scott Howard Dickerson, Stephen Vernon Frye, Philip Anthony Harris, Robert Neil Hunter III, Lee Frederick Kuyper, Karen Elizabeth Lackey, Michael Joseph Luzzio, James Marvin Veal, Duncan Herrick Walker: Substituted oxindole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors and compositions and methods of treating chemotherapy and radiation therapy side effects. SmithKline Beecham Corporation, Jennifer L Fox, September 12, 2006: US07105529 (34 worldwide citation)

Compounds of formula (I): wherein X is N, CH, CCF3, or C(C1-12 aliphatic); R4 is sulfonic acid, C1-12 aliphatic-sulfonyl, sulfonyl-C1-12 aliphatic, C1-12 aliphatic-sulfonyl-C1-6 aliphatic, C1-6 aliphatic-amino, R7-sulfonyl, R7 sulfonyl-C1-12 aliphatic, R7-aminosulfonyl, R7-aminosulfonyl-C1-12 alipha ...


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Matthew Lee Brown, Mui Cheung, Scott Howard Dickerson, Cassandra Gauthier, Philip Anthony Harris, Robert Neil Hunter, Gregory Pacofsky, Michael Robert Peel, Jeffrey Alan Stafford: 1,3-Oxazole compounds for the treatment of cancer. SmithKline Beecham Corporation, John L Lemanowicz, Jennifer L Fox, March 13, 2007: US07189712 (7 worldwide citation)

Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.


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George Adjabeng, Jerry Leroy Adams, Scott Howard Dickerson, Keith Hornberger, Neil W Johnson, Kevin Kuntz, Kimberly Petrov, Jeffrey M Ralph, Tara Renae Rheault, Gregory Schaaf, John Stellwagen, Xinrong Tian, David E Uehling, Alex G Waterson, Brian Wilson: Benzene sulfonamide thiazole and oxazole compounds. Glaxo SmithKline, J Scott Young, April 9, 2013: US08415345 (5 worldwide citation)

The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.


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David Edward Uehling, Kirk Lawrence Stevens, Scott Howard Dickerson, Alex Gregory Waterson, Philip Anthony Harris, Douglas McCord Sammond, Robert Dale Hubbard, Holly Kathleen Emerson, Joseph W Wilson: 2-pyrimidinyl pyrazolopyridine ErbB kinase inhibitors. GlaxoSmithKline, J Scott Young, October 12, 2010: US07812022 (5 worldwide citation)

The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.


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Scott Howard Dickerson, Robert N Hunter, Lee Frederick Kuyper, Karen Elizabeth Lackey, Michael J Luzzio, Edgar Raymond Wood III: Substituted oxindole derivatives as tyrosine kinase inhibitors. SmithKline Beecham Corporation, John L Lemanowicz, July 4, 2006: US07071217 (4 worldwide citation)

The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signa ...