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Brus Ronald Hendrik Peter, Uytdehaag Alphonsus Gerardus Cornelis Maria, Schouten Govert Johan: Methodes didentification de composes antiviraux, Methods for the identification of antiviral compounds. Crucell Holland, Crucell Holland, Borden Ladner Gervais, May 24, 2011: CA2445911

The present invention provides novel methods for determining whether a compound influences a phase in the life cycle of a virus comprising providing a cell with said compound and with at least a fragment of said virus sufficient for performing said phase and determing whether said phase is influence ...


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Vogels Ronald, Schouten Govert Johan, Bout Abraham, Havenga Menzo Jans Emco: Transduction de cellules ressemblant a des fibroblastes ou a des macrophages et moyens a cet effet, Means and methods for fibroblast-like or macrophage-like cell transduction. Introgene, Crucell Holland, BORDEN LADNER GERVAIS, September 8, 2000: CA2364499

The invention provides a nucleic acid delivery vehicle with or having been provided with at least a tissue tropism for fibroblast-like or macrophage-like cells, preferably synoviocytes. In one aspect said nucleic acid delivery vehicle is a virus capsid or a functional part, derivative and/or analogu ...


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Pau Maria Grazia, Uytdehaag Alphonsus Gerardus Cornelis Maria, Schouten Govert Johan: Fabrication de vaccins, Production of vaccines. Crucell Holland, Crucell Holland, Borden Ladner Gervais, March 29, 2011: CA2392653

Novel means and methods are provided for the production of mammalian viruses, comprising infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing ...


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Valerio Domenico, Schouten Govert Johan, Plasterk Ronald Hans Anton, Van Luenen Hendricus Gerhard A: Vectors and methods for providing cells with additional nucleic acid material integrated in the genome of said cells. Kanker Inst Nl, Introgene, May 31, 2000: EP1003899-A1

The present invention provides novel elements for improving genetic engineering techniques for producing recombinant nucleic acid molecules and/or recombinant cells. The novel elements are capable of integrating desired necleic acid material into other nucleic acid materials, specifically into the g ...


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