1
Pau Maria Grazia, Uytdehaag Alphonsus Gerardus C, Schouten Govert Johan: Production of vaccines. Crucell Holland, June 20, 2001: EP1108787-A2 (15 worldwide citation)

Novel means and methods are provided for the production of mammalian viruses, comprising infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing ...


2
Uytdehaag Alphonsus Gerardus Cornelis Maria, Schouten Govert Johan, Goudsmit Jaap: Vaccines against west nile virus. Crucell Holland, Uytdehaag Alphonsus Gerardus Cornelis Maria, Schouten Govert Johan, Goudsmit Jaap, KLEIN Bart, May 21, 2004: WO/2004/042042 (9 worldwide citation)

The present invention relates to novel vaccines containing (whole-inactivated) West Nile Viruses and/or West Nile viral proteins derived there from, produced on human cells, wherein the human cells comprise a sequence encoding at least one early region-1 (El) gene product of an adenovirus. The cells ...


3
Hateboer Guus, Verhulst Karina Cornelia, Schouten Govert Johan, Uytdehaag Alphonsus Gerardus Cornelis Maria, Bout Abraham: Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein. Crucell Holland, Hateboer Guus, Verhulst Karina Cornelia, Schouten Govert Johan, Uytdehaag Alphonsus Gerardus Cornelis Maria, Bout Abraham, PRINS A W, October 26, 2000: WO/2000/063403 (2 worldwide citation)

The present invention provides methods and compositions for the production of recombinant proteins in a human cell line, using sequences encoding at least one E1 protein of an adenovirus where the cells does not encode a structural adenoviral protein from its genome. The methods and compositions are ...


4

5
SCHOUTEN GOVERT JOHAN: Adjuvanted vaccine formulations. MUCOSIS, Jansen Cm, April 7, 2011: WO/2011/040811 (1 worldwide citation)

The invention relates to adjuvanted vaccine formulations, in particular influenza vaccines for intranasal delivery. Provided is an adjuvanted influenza vaccine formulation, comprising (i) peptidoglycan microparticles obtained from a Gram-positive bacterium and (ii) at least one influenza virus antig ...


6
SCHOUTEN GOVERT JOHAN, LEENHOUTS CORNELIS JOHANNES: Adjuvanted intranasal vaccine formulations, Intranasale Adjuvansimpfstoffformulierungen, Formulations de vaccin intranasal avec adjuvants. MUCOSIS, April 13, 2011: EP2308506-A1

The invention relates to adjuvanted vaccine formulations, in particular influenza vaccines for intranasal delivery. Provided is an adjuvanted influenza vaccine formulation, comprising (i) peptidoglycan microparticles obtained from a Gram-positive bacterium and (ii) at least one influenza virus antig ...


7
Schouten Govert Johan, Vogels Ronald, Opstelten Dirk Jan Elbertus: Modified adenoviral vectors for use in gene therapy. Introgene, March 14, 2001: EP1083228-A1

The invention provides a method for producing a recombinant adenovirus-like gene delivery vehicle having reduced expression of adenoviral E2B and/or E4 gene products in a target cell for gene therapy, comprising generating a recombinant adenoviral vector lacking E1A and preferably E1B sequences, but ...


8
Brus Ronald Hendrik Peter, Uytdehaag Alphonsus Gerardus C, Schouten Govert Johan: Methods for the identification of antiviral compounds. Crucell Holland, November 13, 2002: EP1256803-A1

The invention is concerned among other with means and method for determining whether a compound influences a phase in the life cycle of a virus. The invention utilizes the striking observation that cells comprising a nucleic acid encoding an adenovirus early protein or a functional part, derivative ...


9
HATEBOER GUUS, VERHULST KARINA CORNELIA, UYTDEHAAG ALPHONSUS GERARDUS CORNELIS MARIA, SCHOUTEN GOVERT JOHAN, BOUT ABRAHAM: [fr] Production de protéine recombinant de cellules humaines comportant au moins une E1 protéine à ladenovirus, [de] Herstellung von rekombinanten Proteinen in einer menschlichen Zelle mit mindestens einem E1 adenovirus Protein, [en] Recombinant protein production in a human cell comprising at least one E1 protein of adenovirus. CRUCELL HOLLAND, March 17, 2010: EP2163640-A1

[en] The present invention provides methods and compositions for the production of recombinant proteins in a human cell line. The methods and compositions are particularly useful for generating stable expression of human recombinant proteins of interest that arc modified post-translationally, e.g. b ...


10


Click the thumbnails below to visualize the patent trend.