Bichon Daniel, Bussat Philippe, Schneider Michel: Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography.. Sint, November 27, 1991: EP0458745-A1 (292 worldwide citation)

Air or gas filled microballoons bounded by an interfacially deposited polymer membrane which can be dispersed in aqueous carrier liquids to be injected into living organisms or administered orally, rectally and urethrally for therapeutic or diagnostic purposes (echography). The properties of the pol ...

Schneider Michel, Yan Feng, Grenier Pascal, Puginier Jerome, Barrau Marie Bernadette: Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof.. Sint, August 4, 1993: EP0554213-A1 (183 worldwide citation)

One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of ...


Schneider Michel, Tournier Herve, Lamy Bernard: Injectable opacifying liposome composition.. Bracco Ind Chimica, May 10, 1989: EP0314764-A1 (73 worldwide citation)

Injectable aqueous composition intended for opacifying certain organs with a view to examination by X-rays. This composition is based on liposomes containing, encapsulated therein, an aqueous solution of an iodinated opacifying agent. The ratio between the weight of iodine encapsulated by the liposo ...

Schneider Michel, Bussat Philippe, Yan Feng, Guillot Christian: Ultrasound contrast agents and process for the preparation thereof. Bracco International, Schneider Michel, Bussat Philippe, Yan Feng, Guillot Christian, RAVIZZA Claudio, August 19, 2004: WO/2004/069284 (24 worldwide citation)

Method for preparing a lyophilized matrix and, upon reconstitution of the same, a respective injectable contrast agent comprising a liquid aqueous suspension of gas-filled microbubbles stabilized predominantly by a phospholipid. The method comprises preparing an emulsion from an aqueous medium, a ph ...


Yan Feng, Schneider Michel, Brochot Jean: Gas mixtures useful as ultrasound contrast media.. Bracco Research, November 22, 1995: EP0682530-A1 (13 worldwide citation)

The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and stabilisers prov ...

Tournier Hervé, Hyacinthe Roland, Schneider Michel: Liposomal assembly for therapeutic and/or diagnostic use. Bracco Research, Tournier Hervé, Hyacinthe Roland, Schneider Michel, December 15, 2005: WO/2005/117832 (12 worldwide citation)

Composition for diagnostic or therapeutic use whichcomprises an assembly comprising an active agent. The assembly comprises a Iiposome and a plurality of micellar components associated thereto, said micellar components being associated to the outer surface of the envelope of said liposome through a ...