1
Gant Thomas G, Sarshar Sepehr: Substituted n-aryl pyridinones as fibrotic inhibitors. Auspex Pharmaceutical, Gant Thomas G, Sarshar Sepehr, BENNETT Dennis A, December 24, 2008: WO/2008/157786 (13 worldwide citation)

Disclosed herein are substituted N-Aryl pyridinone fibrotic inhibitors and/or collagen infiltration modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.


2
Mjalli Adnan Mukhabur, Sarshar Sepehr: Substituted imidazoles as modulators of multi-drug resistance. Ontogen, December 17, 1997: EP0812829-A1 (11 worldwide citation)

This invention relates to compounds of Formula 1 which are pharmacologically useful for the treatment of cancer through sensitization of multi-drug resistant cancer cells to chemotherapeutic agents. wherein R1, R2, R3, and R4 are, for example, alkyl, aryl, etc., which are defined more specifically h ...


3
Sarshar Sepehr: Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders. Auspex Pharmaceuticals, Sarshar Sepehr, HAILE Lisa A, March 8, 2007: WO/2007/028104 (8 worldwide citation)

The present invention is directed to novel compounds according to formula (I) wherein R1, R2, and X are as defined herein. The invention also discloses methods of preparation, pharmaceutical compositions, and methods of disease treatment utilizing pharmaceutical compositions comprising these compoun ...


4
Gant Thomas G, Sarshar Sepehr: Deuterated tadalafil derivatives. Auspex Pharmaceuticals, Gant Thomas G, Sarshar Sepehr, INSOGNA Anthony M, December 21, 2007: WO/2007/146124 (8 worldwide citation)

Provided herein are substituted PDE5 inhibitors of Formula (1), and processes of preparation and pharmaceutical compositions thereof. Also provided are methods of their use for the treatment and/or management of hypertension, erectile dysfunction, and/or the inability to maintain improved erectile f ...


5
Gant Thomas G, Sarshar Sepehr: Preparation and utility of substituted erythromycin analogs. Auspex Pharmaceuticals, Gant Thomas G, Sarshar Sepehr, HOSTETLER Michael J, December 13, 2007: WO/2007/143507 (7 worldwide citation)

The present disclosure is directed to novel macrolide antibiotics of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof; and the chemical syntheses and medical uses of these novel macrolide antibiotics for the treatment and/or management of infections caused by various aerobic an ...


6
Tse Bruno, Hong Borcherng, Chen Wei Hung, Jiang Yea Fen, Zhang Shuo Cang, Marappan Subramanian, Sarshar Sepehr: Method of preparation of novel nucleoside analogs and uses. Auspex Pharmaceuticals, Tse Bruno, Hong Borcherng, Chen Wei Hung, Jiang Yea Fen, Zhang Shuo Cang, Marappan Subramanian, Sarshar Sepehr, HAILE Lisa A, June 2, 2005: WO/2005/049582 (6 worldwide citation)

Processes for the preparation of racemic and optically active nucleoside analogs of formula (A) are described. These compounds are useful as anti-infective agents, antisense therapeutic agents and hybridization assay probes.


7
Gant Thomas G, Sarshar Sepehr: Substituted deuterium enriched thiophenes for the treatment of hypertension. Auspex Pharmaceuticals, Gant Thomas G, Sarshar Sepehr, BENNETT Dennis A, October 16, 2008: WO/2008/124803 (6 worldwide citation)

Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.


8
Mjalli Adnan Mukhabur, Sarshar Sepehr: Modulators of multi-drug resistances. Ontogen, December 17, 1997: EP0812830-A1 (4 worldwide citation)

The present invention relates to imidazole derivatives having formula 1 wherein: R1 is selected from the group consisting of: mono-,di-,and tri-substituted phenyl or thienyl, the substituents are selected from the group consisting of: (i) substituted C1-6 alkyl, substituted C2-6 alkyloxy, wherein th ...


9
Chu Shao Song, Alegria Larry Andrew, Bender Steven Lee, Benedict Suzanne Pritchett, Borchardt Allen J, Kania Robert Steven, Nambu Mitchell David, Tempczyk Russell Anna Maria, Sarshar Sepehr, Bhumralkar Dilip, Peng Zhengwei, Yang Yi Michelle: Diaminothiazoles and their use for inhibiting protein kinases. Agouron Pharmaceuticals, PINO Mark J, December 14, 2000: WO/2000/075120 (4 worldwide citation)

Diaminothiazole compounds of formula (I) that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell ...


10
Sarshar Sepehr: Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders. Auspex Pharmaceuticals, Sarshar Sepehr, HAILE Lisa A, November 17, 2005: WO/2005/108338 (4 worldwide citation)

The present invention is directed to novel compounds according to formulae (I) wherein R1, R2, R3 and R4 are as defined herein. The invention also discloses methods of preparation, pharmaceutical compositions, and methods of disease treatment utilizing pharmaceutical compositions comprising these co ...