1
Paul Edward Aldrich, Argyrios Georgios Arvanitis, Robert Scott Cheeseman, Robert John Chorvat, Thomas Eugene Christos, Paul Joseph Gilligan, Dimitri Emil Grigoriadis, Carl Nicholas Hodge, Paul John Krenitsky, Everett Latham Scholfield, Sang William Tam, Zelda Rakowitz Wasserman: 1N-alkyl-n-arylpyrimidinamines and derivatives thereof. DuPont Pharmaceuticals Company, Robert W Black, Kenneth B Rubin, Kalim S Fuzail, January 29, 2002: US06342503 (65 worldwide citation)

The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppressi ...


2
David S Garvey, L Gordon Letts, H Burt Renfroe, Sang William Tam: Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs. NitroMed, Charles J Herron, Elliot M Olstein, December 30, 1997: US05703073 (45 worldwide citation)

Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitr ...


3
David S Garvey, L Gordon Letts, H Burt Renfroe, Sang William Tam: Nitroso esters of .beta.-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs. NitroMed, Hale and Dorr, November 7, 2000: US06143734 (37 worldwide citation)

A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a compound comprising an enolic anilide non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO.sub.2 group, a pharmaceutical composition including the com ...


4
David S Garvey, L Gordon Letts, H Burt Renfroe, Sang William Tam: Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs. NitroMed, Hale and Dorr, July 4, 2000: US06083515 (22 worldwide citation)

Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitr ...


5
David S Garvey, L Gordon Letts, H Burt Renfroe, Sang William Tam: Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs. NitroMed, Hale and Dorr, March 28, 2000: US06043233 (22 worldwide citation)

Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitr ...


6
David S Garvey, L Gordon Letts, H Burt Renfroe, Sang William Tam: Methods to treat gastrointestinal lesions and to reduce drug-induced gastrointestinal or renal toxicity. NitroMed, Hale and Dorr, November 27, 2001: US06323234 (21 worldwide citation)

Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; composition comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitro ...


7
David S Garvey, L Gordon Letts, H Burt Renfroe, Sang William Tam: Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs. NitroMed, Hale and Dorr, May 2, 2000: US06057347 (20 worldwide citation)

Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitr ...


8
David S Garvey, L Gordon Letts, H Burt Renfroe, Sang William Tam: Nitroso esters of .beta.-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs. April 18, 2000: US06051588 (17 worldwide citation)

A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a pharmaceutical composition including the compounds and methods of treatment of pain and/or inflammation using the compounds and compositions are disclosed. Also disclosed is a compos ...


9
David S Garvey, L Gordon Letts, H Burt Renfroe, Sang William Tam: Compositions and methods to prevent toxicity induced by nonsteroidal antiflammatory drugs. NitroMed, Hale and Dorr, April 11, 2000: US06048858 (13 worldwide citation)

Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitr ...


10
David S Garvey, L Gordon Letts, H Burt Renfroe, Sang William Tam: Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs. NitroMed, Hale and Dorr, November 19, 2002: US06482846 (13 worldwide citation)

Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitr ...



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