1
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny. NeuroSpheres Holdings, David J Brezner, Jan P Brunelle, Flehr Hohbach Test Albritton & Herbert, May 12, 1998: US05750376 (244 worldwide citation)

A method for producing genetically modified neural cells comprises culturing cells derived from embryonic, juvenile, or adult mammalian neural tissue with one or more growth factors that induce multipotent neural stem cells to proliferate and produce multipotent neural stem cell progeny which includ ...


2
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: In vitro growth and proliferation of multipotent neural stem cells and their progeny. Neurospheres, Flehr Hohbach Test Albrition & Herbert, December 22, 1998: US05851832 (209 worldwide citation)

A method for the in vitro proliferation and differentiation of neural stem cells and stem cell progeny comprising the steps of (a) isolating the cells from a mammal, (b) exposing the cells to a culture medium containing a growth factor, (c) inducing the cells to proliferate, and (d) inducing the cel ...


3
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: Neural transplantation using proliferated multipotent neural stem cells and their progeny. NeuroSpheres Holdings, Ivor R Elrifi Esq, Christine V Karnakis Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, December 24, 2002: US06497872 (111 worldwide citation)

The invention provides methods of transplanting multipotent neural stem cell progeny to a host by obtaining a population of cells derived from mammalian neural tissue containing at least one multipotent CNS multipotent neural stem cell; culturing the neural stem cell in a culture medium containing o ...


4
Samuel Weiss, Brent Reynolds: Growth factor-induced proliferation of neural precursor cells in vivo. NeuroSpheres Holdings, Burns Doane Swecker & Mathis L, November 9, 1999: US05980885 (71 worldwide citation)

A method is described for inducing in vivo proliferation of precursor cells located in mammalian neural tissue by administering to the mammal a fibroblast growth factor and at least one additional growth factor selected from the group consisting of epidermal growth factor, transforming growth factor ...


5
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: In vivo genetic modification of growth factor-responsive neural precursor cells. NeuroSpheres Holdings, Burns Doane Swecker & Mathis L, June 6, 2000: US06071889 (59 worldwide citation)

Methods for administering genetic material to dividing neural precursor cell populations in vivo are provided. The genetic material may comprise useful genes for neurotransmitters, growth factors, growth factor receptors, and the like. The genetic material is administered to the brain with one or mo ...


6
Samuel Weiss, Brent Reynolds: In vitro induction of dopaminergic cells. NeuroSpheres Holdings, Burns Doane Swecker & Mathis L, November 9, 1999: US05981165 (59 worldwide citation)

A culture method for inducing the expression of tyrosine hydroxylase in neural cells is provided. Mammalian CNS neural cells are cultured in the presence of a fibroblast growth factor and at least one selected from a member of the transforming growth factor beta family, a feeder layer bed of cells, ...


7
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents. Neurospheres Holdings, Ivor R Elrifi Esq, Mintz Levin Cohn Ferris Glovsky and Popeo P C, September 25, 2001: US06294346 (44 worldwide citation)

A culture method for determining the effect of a biological agent on multipotent neural stem cell progeny is provided. In the presence of growth factors, multipotent neural stem cells are induced to proliferate in culture. The multipotent neural stem cells may be obtained from normal neural tissue o ...


8
Samuel Weiss, S Todd Sorokan: Erythropoietin-mediated neurogenesis. Neuro Spheres Holdings, Burns Doane Swecker & Mathis, December 26, 2000: US06165783 (44 worldwide citation)

Methods are described for the production of neurons or neuronal progenitor cells. Multipotent neural stem cells are proliferated in the presence of growth factors and erythropoietin which induces the generation of neuronal progenitor cells. The erythropoietin may be exogenously applied to the multip ...


9
Christopher Gregg, Samuel Weiss: Pregnancy-induced oligodendrocyte precursor cell proliferation regulated by prolactin. Stem Cell Therapeutics, Fish & Richardson P C, May 19, 2009: US07534765 (18 worldwide citation)

The present invention relates to a method to increase oligodendrocytes and oligodendrocyte precursor cells through administration of prolactin or a prolactin inducing agent.


10
Samuel Weiss, Brent Reynolds, Joseph P Hammang, E Edward Baetge: Methods of screening biological agents. Neurospheres Holdings, Mintz Levin Cohn Ferris Glovsky and Popeo P C, Ivor R Elrifi, Christina K Stock, September 5, 2006: US07101709 (18 worldwide citation)

The invention discloses methods of proliferation and differentiation of multipotent neural stem cells. Also provided are methods of making cDNA libraries and methods of screening biological agents which affect proliferation differentiation survival phenotype or function of CNS cells.