1
Yabe Yuichiro, Sakurai Mitsuya, Higashida Susumu, Komai Tomoaki, Nishigaki Takashi, Handa Hiroshi: New beta-amino-alpha-hydroxycarboxylic acids and their use.. Sankyo, August 12, 1992: EP0498680-A1 (58 worldwide citation)

The compounds of the invention are beta -amino- alpha -hydroxycarboxylic acid derivatives having the formula (I): wherein: R represents a group of formula R(Z)xA- wherein R is hydrogen, or a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclic group or R is a group of formula - ...


2
Higashida Susumu C O Sankyo Co, Sakurai Mitsuya C O Sankyo Com, Yabe Yuichiro C O Sankyo Comp, Nishihgaki Takashi C O Sankyo, Komai Tomoaki C O Sankyo Comp, Handa Hiroshi C O Sankyo Comp: Peptides capable of inhibiting the activity of hiv protease, their preparation and their therapeutic use.. Sankyo, March 16, 1994: EP0587311-A1 (31 worldwide citation)

Compounds of formula (I) : [wherein: R is hydrogen, alkyl, aralkyl, -COR, -COR, -CSR, -CSR, -SO2R, -CONHR, -CSNHR, -CONRR or -CSNRR; R is hydrogen or alkyl; R is hydrogen, alkylidene, substituted alkyl, or R; R is optionally substituted alkyl, cycloalkyl, or aryl; R is RO-, RRN-, RHN-, aralkyloxycar ...


3
Yanagisawa Hiroaki, Sakurai Mitsuya, Takamura Makoto, Fujiwara Toshihiko: Amidocarboxylic acid derivatives. Sankyo, August 9, 2000: EP1026149-A1 (13 worldwide citation)

Amidocarboxylic acid derivatives of the formula: Äwherein R represents a hydrogen atom, etc.; R represents an alkylene group; R represents a hydrogen atom, etc; R represents a hydrogen atom, etc., X represents a substituted or unsubstituted aryl group, etc.; Y represents an oxygen atom, etc.; Z repr ...


4
Yanagisawa Hiroaki, Sakurai Mitsuya, Takamura Minoru, Fujiwara Toshihiko: Ameliorating agent for glycometabolism and lipid metabolism. Sankyo, December 12, 2000: JP2000-344666 (5 worldwide citation)

PROBLEM TO BE SOLVED: To obtain a new compound having strong hypoglycemic action, hypolipidemic action, insulin resistance-ameliorating action, etc., and useful as a prophylactic and/or therapeutic agent e.g. for insulin resistance diseases, inflammatory diseases and neurological diseases.SOLUTION: ...


5
Yanagisawa Hiroaki, Sakurai Mitsuya, Takamura Makoto: Amidocarboxylic acid derivatives. Sankyo, liu yuanjin, January 17, 2001: CN98811630

Amidocarboxylic acid derivatives represented by general formula (I), pharmacologically acceptable salts thereof, or pharmacologically acceptable esters thereof, wherein R represents a hydrogen atom or the like; R represents an alkylene group; R represents a hydrogen atom or the like; R represents a ...


6
Yanagisawa Hiroaki, Sakurai Mitsuya, Takamura Makoto, Fujiwara Toshihiko: Amidocarboxylic acid derivatives. Sankyo Company, Yanagisawa Hiroaki, Sakurai Mitsuya, Takamura Makoto, Fujiwara Toshihiko, OHNO Akio, April 15, 1999: WO/1999/018066

Amidocarboxylic acid derivatives represented by general formula (I), pharmacologically acceptable salts thereof, or pharmacologically acceptable esters thereof, wherein R?1¿ represents a hydrogen atom or the like; R?2¿ represents an alkylene group; R?3¿ represents a hydrogen atom or the like; R?4¿ r ...


7
Yabe Yuichiro, Sakurai Mitsuya, Higashida Susumu, Komai Tomoaki, Nishigaki Takashi, Handa Hiroshi: Beta-amino-alpha-hydroxycarboxylic acid derivative. Sankyo, February 20, 1996: JP1996-048627

PURPOSE: To obtain the subject new compound having excellent protease inhibitory activity derived from HIV. CONSTITUTION: This new compound, a β-amino-a-hydroxycarboxylic acid derivative, is selected from: (2S,3S)-3-[N-(2-indolecarbonyl)-L-asparaginyl] amino-2- hydroxy-4-phenylbutyryl-L-proline t-bu ...


8
Yabe Yuichiro, Sakurai Mitsuya, Nishigaki Takashi, Ozawa Yuji, Komai Tomoaki, Nakagawa Akihiko: Ahpba-containing dipeptide derivative. Sankyo, February 13, 1996: JP1996-041023

PURPOSE: To obtain a new dipeptide derivative specific to HIV protease and having excellent inhibitory activity thereon, thus useful as an anti-AIDS agent. CONSTITUTION: This compound, a 3-amino-2-hydroxy-4-phenylbutanoic acid-contg. dipeptide derivative, is expressed by formula I [R1 is an alkyl, a ...


9
Higashida Susumu, Sakurai Mitsuya, Yabe Yuichiro, Nishigaki Takashi, Komai Tomoaki, Handa Hiroshi: Peptide derivative exhibiting hiv protease inhibitory activity. Sankyo, April 12, 1994: JP1994-100533

PURPOSE: To provide a new peptide derivative exhibiting an excellent inhibitory activity on HIV-derived protease, free from toxicity and useful as a medicine for improving AIDS. CONSTITUTION: A compound of the formula [R1 is H, an alkyl, an aralkyl, a substituted (thio)carbonyl, a substituted sulfon ...


10
Yabe Yuichiro, Sakurai Mitsuya, Higashida Susumu: Production of dipeptide-equivalent material. Sankyo, February 1, 1994: JP1994-025124

PURPOSE: To stereoselectively produce the subject compound by reacting zinc with a β-halogen carbonyl compound producible from an easily available β- hydroxy carbonyl compound through two steps and reacting the product with an acid halide in the presence of a transition metal. CONSTITUTION: A ketome ...