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Higuchi Naoki, Saitoh Masayuki, Shibata Hiroshi: Proteinase inhibitor.. Suntory, October 24, 1990: EP0393457-A1 (170 worldwide citation)

A proteinase inhibitory compound represented by the following general formula (1): wherein R1 represents a straight-chain or branched acyl group having 2 to 10 carbon atoms, a branched-, cyclic- or polycyclic-alkyloxycarbonyl group having 4 to 15 carbon atoms, a substituted- or unsubstituted-benzylo ...


2
Kiso Yoshinobu, Hayashi Yasuhiro, Higuchi Naoki, Saitoh Masayuki, Hashimoto Masaki: Prophylactic and therapeutic agent for bone diseases comprising di- or tripeptide derivative as active ingredient.. Suntory, September 23, 1992: EP0504938-A2 (63 worldwide citation)

Use of a compound represented by the following general formula (I): wherein R represents a straight or branched acyl group having 2 to 10 carbon atoms, a branched cyclic or bridged cyclic alkyloxycarbonyl group having 4 to 15 carbon atoms, a substituted or unsubstituted benzyloxycarbonyl group, a 2, ...


3
Higuchi Naoki, Saitoh Masayuki, Niwata Shinjiro, Kiso Yoshinobu, Hayashi Yasuhiro: Dipeptide derivative and prophylactic and therapeutic agent for bone diseases containing the same.. Suntory, May 26, 1993: EP0543310-A2 (30 worldwide citation)

A prophylactic or therapeutic agent for malignant hypercalcemia, bone Paget's disease and osteoporosis is disclosed, which contains as an active ingredient a dipeptide derivative represented by formula: RNH-CH(R)-CO-NH-CH(R)-R (I> wherein R represents an aliphatic acyl group, a halogen-substituted a ...


4
Fukami Harukazu, Sumida Motoo, Niwata Shinjiro, Kakutani Saki, Saitoh Masayuki, Shibata Hiroshi, Kiso Yoshinobu: Imidazolidine derivative and use thereof. Suntory, July 17, 1996: EP0721944-A1 (24 worldwide citation)

The invention relates to an imidazolidine derivative represented by the following general formula (1): wherein A and B mean individually an aromatic hydrocarbon group which may be substituted by 1-3 substituents selected from halogen atoms, C1-4 alkyl groups, C1-4 alkoxy groups, C1-4 alkylenedioxy g ...


5
Tanaka Takaharu, Saitoh Masayuki, Hashimoto Masaki, Higuchi Naoki: N-acylpyrrolidine derivatives, processes for preparing them, pharmaceutical composition and use.. Suntory, November 20, 1986: EP0201742-A2 (23 worldwide citation)

A novel compound that exhibits inhibitory activity against prolyl endopeptidase and a method for chemical synthesis of said compound, as well as its use as a prolyl endopeptidase inhibitor and an anti-amnesic agent that contains said compound as the active ingredient are provided.


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Nunokawa Yoichi, Suzuki Kenji, Saitoh Masayuki: Nf-kb inhibitors containing benzoquinone derivatives. Suntory, June 14, 2000: EP1008346-A1 (13 worldwide citation)

NF-kB inhibitors containing as the active ingredient benzoquinone derivatives represented by general formula (I), hydroquinone compounds thereof or salts of the same, wherein R1, R2 and R3 independently represent each H, C1-5 alkyl or C1-5 alkoxy; R4 represents H, hydroxy-methyl, alkyl or optionally ...


9
Saitoh Masayuki, Hamada Mitsuo: Method for curing organosiloxane compositions.. Toray Silicone Co, October 7, 1987: EP0239819-A2 (10 worldwide citation)

A cured silicone rubber is produced by heating at a temperature of at least 150 degrees C. under a pressure of at least 9.8 kilopascals pressure a silicone rubber composition comprising an alkenyl-containing organopolysiloxane, an organohydrogensiloxane and finely divided silica in the absence of a ...


10
Higuchi Naoki, Saitoh Masayuki, Niwata Shinjiro, Kiso Yoshinobu, Hayashi Yasuhiro: Dipeptide derivative and prophylactic or therapeutic agent for bone diseases containing same as active ingredient.. Suntory, January 19, 1994: EP0578978-A1 (10 worldwide citation)

A dipeptide derivative having the formula (I): RNH-CH(R)-CO-NH-CH(R)-COCH2F (I> wherein, R is an aliphatic acyl group having 2 to 8 carbon atoms or a benzyloxycarbonyl group; and R and R are independently a hydrogen atom or a straight or branched alkyl group having 1 to 4 carbon atoms and a prophyla ...