1
Bala Subramaniam, Said Saim, Roger A Rajewski, Valentino Stella: Methods for a particle precipitation and coating using near-critical and supercritical antisolvents. The University of Kansas, Hovey Williams Timmons & Collins, November 10, 1998: US05833891 (112 worldwide citation)

Improved methods and apparatus for particle precipitation and coating using near- or supercritical fluid conditions are described. A fluid dispersion having a continuous phase dispersant and at least one precipitatable substance therein is contacted with a supercritical fluid (SCF) antisolvent so as ...


2
Bala Subramaniam, Said Saim, Roger A Rajewski, Valentino Stella: Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent. The University of Kansas, Hovey Williams Timmons & Collins, February 23, 1999: US05874029 (66 worldwide citation)

A method and an apparatus useful for the production of microparticles and nanoparticles are disclosed in which a compressed fluid and a solution including a solvent and a solute are introduced into a nozzle to produce a mixture. The mixture is then passed out of the nozzle to produce a spray of atom ...


3
Bala Subramaniam, Said Saim: In situ mitigation of coke buildup in porous catalysts with supercritical reaction media. Center For Research, Hovey Williams Timmons & Collins, March 10, 1998: US05725756 (40 worldwide citation)

A method to minimize catalyst deactivation rate and coke laydown, and maximize desired reaction rate in processing of industrially significant reactions under supercritical conditions to generate a reaction mixture stream including formed reaction products and reactants, said contacting at a desired ...


4
Stephen T Horhota, Said Saim: Method for extraction and reaction using supercritical fluids. Boehringer Ingelheim Pharmaceuticals, Robert P Raymond, Alan R Stempel, Mary Ellen M Devlin, September 25, 2001: US06294194 (35 worldwide citation)

Methods for removing soluble material from confined spaces within substrates such as containers, capsules and porous powders comprising extraction with supercritical fluids, the pressure of which is preferably modulated between an upper level and a lower level within a relatively narrow range of flu ...


5
David L Stalling, Congyuan Guo, Kenneth C Kuo, Kevin P Kelly, Said Saim: Chemically bound fullerenes to resin and silica supports and their use as stationary phases for chromatography. Analytical Bio Chemistry Laboratories, May 3, 1994: US05308481 (26 worldwide citation)

The present invention relates to buckminsterfullerenes or related condensed carbon molecules covalently bonded to a polymer particle or a siliceous support particle and their use for packing media for column chromatography.


6
David L Stalling, Said Saim: Integrated instrument for supercritical fluid sample extraction, sample separation and concentration. Analytical Bio Chemistry Laboratories, March 30, 1993: US05198115 (26 worldwide citation)

An integrated sample extraction and separation system includes a number of substantially identical supercritical fluid extraction modules and sample separation modules connected in common to a source of supercritical fluid and modifier and to instruments for sample analysis. Each of the supercritica ...


7
Bala Subramaniam, Said Saim, Michael C Clark: In situ mitigation of coke buildup in porous catalysts by pretreatment of hydrocarbon feed to reduce peroxides and oxygen impurities. Center for Research, Hovey Williams Timmons & Collins, November 25, 1997: US05690809 (24 worldwide citation)

An improved process is provided for in situ mitigation of coke buildup and porous catalyst used for the processing of hydrocarbon feed stocks. The process exhibits improved catalyst activity over extended periods and the process comprises the pretreatment of hydrocarbon feed stocks to reduce impurit ...


8
David L Stalling, Said Saim, Congyuan Guo, Kenneth Kuo: Recovery of C.sub.60 and C.sub.70 buckminsterfullerenes from carbon soot by supercritical fluid extraction and their separation by adsorption chromatography. Analytical Bio Chemistry Laboratories, January 25, 1994: US05281406 (17 worldwide citation)

A process has been developed to effectively separate and recover essentially pure amounts of both C.sub.60 and C.sub.70 from carbon soot and higher molecular weight fullerenes. This process first extracts the fullerenes from carbon soot and then sequentially separates the C.sub.60 and C.sub.70 molec ...


9
Fabrice Gallou, Said Saim, Nathan K Yee: Removal of ruthenium by-product by supercritical fluid processing. Boehringer Ingelheim International, Michael P Morris, Mary Ellen M Devlin, Philip I Datlow, September 11, 2007: US07268211 (7 worldwide citation)

A process for removing ruthenium or ruthenium-containing compounds from a reaction mixture comprising a compound of the following formula I in an organic solvent using supercritical fluid processing techniques: wherein RA, R3, R4, D and A are as defined herein. This invention has particular applicat ...


10
Stephen T Horhota, Said Saim: Supercritical fluid extraction of mould lubricant from hard shell capsules. Boehringer Ingelheim Pharmaceuticals, Robert P Raymond, Alan R Stempel, Mary Ellen M Devlin, May 8, 2001: US06228394 (6 worldwide citation)

Hard shelled capsules and dry, powdered pharmaceutical formulations are treated with supercritical fluids to remove impurities such as mold lubricants and moisture.