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Safe Stephen H, Chintharlapalli Sudhakar, Mcalees Alan, Mccrindle Robert: Glycyrrhetinic acid derivatives. Wellington Laboratories, The Texas A & M University System, Safe Stephen H, Chintharlapalli Sudhakar, Mcalees Alan, Mccrindle Robert, BERESKIN PO Box 401 40 King Street West Toronto Ontario M5H 3Y2, January 3, 2008: WO/2008/000070 (25 worldwide citation)

The present invention relates to novel derivatives of glycyrrhetimc acid of Formula (I), compositions comprising said derivatives and their use in the treatment of conditions or diseases that benefit from an upregulation of PPAR&ggr; and/or a downregulation of the expression or activity of one or mo ...


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Safe Stephen H, Chintharlapalli Sudhakar: Betulinic acid, derivatives and analogs thereof and uses therefor. The Texas A & M University System And Safe Et Al, ADLER Benjamin A, May 29, 2008: WO/2008/063318 (7 worldwide citation)

Provided herein provided herein are novel analogs and derivatives of betulinic acid. Also provided is a method for inhibiting an activity of one or more specificity protein (Sp) transcription factors cells associated with a neoplastic disease using betulinic acid, betulinic acid analog(s) and/or der ...


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Safe Stephen H, Chintharlapalli Sudhakar, Mertens Talcott Susanne U: Antisense microrna and uses therefor. The Texas A & M University, System, ADLER Benjamin Aaron, February 5, 2009: WO/2009/017803 (1 worldwide citation)

Provided herein are methods to suppress specificity protein (Sp) activity in a cell associated with a cell proliferative disease. The methods are effective to inhibit a microRNA in the cell using an antisense microRNA oligonucleotide which results in an increase in expression of a specificity protei ...


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Safe Stephen H: Indole-3-carbinol, diindolylmethane et analogues substitues utilises comme anti-oestrogenes, Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens. The Texas A & M University System, The Texas A & M University System, Mbm Intellectual Property Law, November 17, 2009: CA2283520

Provided in the present invention are compounds and compositions of substituted indole-3-carbinols having the structure:(see formula I)and diindolylmethane having the structure:(see formula II)suitable for treating-dependent tumors. Also provided are methods of treating such cancerous-conditions.


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Safe Stephen H, Chintharlapalli Sudahkar: Ligand-dependant activation of nur77 and uses thereof. Texas A & M Univ Sys, June 13, 2007: EP1793820-A2

The present invention provides a method for inducing ligand-dependant Nur77 activation in a cell by contacting the cell with an effective dose of an agonist of Nur77. Also provided is a method for treating a mammal having a disease affected by modulation of Nur77 activity as well as a method for ind ...


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Safe Stephen H, Abdelrahim Maen: Uses of diphenyl/diphenylamine carboxylic acids. Texas A &Amp, M Univ System And, December 10, 2008: EP1998763-A2

The present invention demonstrates that chemical-induced degradation of Sp proteins by a specific sub-class of NSAIDs inhibited cancer cell growth, angiogenesis and metastasis of cancer cells. The inhibitory effects of these compounds were demonstrated in vitro and in vivo. Hence, the results discus ...


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Safe Stephen H, Chintharlapalli Sudhakar, Mcalees Alan, Mccrindle Robert: Glycyrrhetinic acid derivatives. Wellington Lab, Texas A & M Univ Sys, March 11, 2009: EP2032594-A1

The present invention relates to a new method of preparing 2-iodo triterpenoid and related compounds via the reaction of the corresponding 1 ene-3-ones in the presence of iodine and pyridine in an ether solvent. The method is particularly suited to steroids such as cholesterol derivatives and pentac ...


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Safe Stephen H: Alkyl-substituted pcdf as a treatment for prostate cancer. Texas A & M Univ Sys, December 28, 2005: EP1608306-A2

The present invention is directed to a method of modulating a prostate neoplasm by administering an alkyl-substituted PCDF.


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Safe Stephen H: Alkyl-substituted pcdf as a treatment for prostate cancer. Texas A & M University System, Safe Stephen H, ACOSTA Melissa W, April 14, 2005: WO/2005/032452

The present invention is directed to a method of modulating a prostate neoplasm by administering an alkyl-substituted PCDF.