1
Ginger A Abraham, Robert M Carr Jr, Paul D Kemp, Ryan D Mercer, Linda Baker: Chemical cleaning of biological material. Organogenesis, Wilmer Cutler Pickering Hale and Dorr, May 17, 2005: US06893653 (38 worldwide citation)

The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali ...


2
Thomas R Alessi, Ryan D Mercer, Catherine M Rohloff, Bing Yang: Suspension formulations of insulinotropic peptides and uses thereof. Intarcia Therapeutics, Gary R Fabian, Barbara G McClung, October 30, 2012: US08299025 (9 worldwide citation)

A suspension formulation of an insulinotropic peptide (e.g., glucagon-like peptide-1 (GLP-1) or exenatide) is described. The suspension formulation comprises (i) a non-aqueous, single-phase vehicle, comprising one or more polymer and one or more one solvent, wherein the vehicle exhibits viscous flui ...


3
Thomas R Alessi, Ryan D Mercer, Catherine M Rohloff, Bing Yang: Osmotic delivery comprising an insulinotropic peptide and uses thereof. Intarcia Therapeutics, Cooley, Ivor Elrifi, January 27, 2015: US08940316 (6 worldwide citation)

A suspension formulation of an insulinotropic peptide (e.g., glucagon-like peptide-1 (GLP-1) or exenatide) is described. The suspension formulation comprises (i) a non-aqueous, single-phase vehicle, comprising one or more polymer and one or more one solvent, wherein the vehicle exhibits viscous flui ...


4
Thomas R Alessi, Karling Alice Leung, Ryan D Mercer, Cristina G Negulescu, Catherine M Rohloff, Bing Yang: Devices, formulations, and methods for delivery of multiple beneficial agents. Intarcia Therapeutics, Cooley, Ivor Elrifi, January 6, 2015: US08926595 (6 worldwide citation)

The present invention relates to osmotic delivery devices, formulations, and methods for delivery of two or more beneficial agents. In one aspect, the present invention provides osmotic delivery devices useful for substantially concurrent administration of two or more beneficial agents. In another a ...


5
Thomas R Alessi, Karling Alice Leung, Ryan D Mercer, Cristina G Negulescu, Catherine M Rohloff, Bing Yang: Devices, formulations, and methods for delivery of multiple beneficial agents. Intarcia Therapeutics, Gary R Fabian, Barbara G McClung, January 1, 2013: US08343140 (6 worldwide citation)

The present invention relates to osmotic delivery devices, formulations, and methods for delivery of two or more beneficial agents. In one aspect, the present invention provides osmotic delivery devices useful for substantially concurrent administration of two or more beneficial agents. In another a ...


6
Ginger A Abraham, Robert M Carr, Paul D Kemp, Ryan D Mercer, Linda Baker: Chemical cleaning of biological material. Organogenesis, Hale And Dorr, January 8, 2004: US20040005703-A1

The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali ...


7
Thomas R Alessi, Ryan D Mercer, Catherine M Rohloff, Bing Yang: Suspension formulations of insulinotropic peptides and uses thereof. Intarcia Therapeutics, October 23, 2008: US20080260840-A1

A suspension formulation of an insulinotropic peptide (e.g., glucagon-like peptide-1 (GLP-1) or exenatide) is described. The suspension formulation comprises (i) a non-aqueous, single-phase vehicle, comprising one or more polymer and one or more one solvent, wherein the vehicle exhibits viscous flui ...


8
Ginger A Abraham, Robert M Carr, Paul D Kemp, Ryan D Mercer, Linda Baker: Chemical cleaning of biological material. Organogenesis, Wilmer Cutler Pickering Hale And Dorr, February 2, 2006: US20060024380-A1

The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali ...


9
Thomas R Alessi, Karling Alice Leung, Ryan D Mercer, Cristina G Negulescu, Catherine M Rohloff, Bing Yang: Devices, formulations, and methods for delivery of multiple beneficial agents. Intarcia Therapeutics, August 13, 2009: US20090202608-A1

The present invention relates to osmotic delivery devices, formulations, and methods for delivery of two or more beneficial agents. In one aspect, the present invention provides osmotic delivery devices useful for substantially concurrent administration of two or more beneficial agents. In another a ...


10
Thomas R Alessi, Ryan D Mercer, Catherine M Rohloff, Bing Yang: Highly concentrated drug particles, formulations, suspensions and uses thereof. Intarcia Therapeutics, April 15, 2010: US20100092566-A1

Highly concentrated drug particle formulations are described, wherein the drug comprises between about 25 wt % and 80 wt % of the particle formulation. The particle formulations of the present invention comprise, for example, macromolecules, such as proteins and/or small molecules (such as steroid h ...