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Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Birong Zhang, Christine Chabot, Steven Do: Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Covenentech, Viksnins Harris & Padys PLLP, November 22, 2011: US08063050 (25 worldwide citation)

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatmen ...


2
Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Jun Li, Christine Chabot: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Genertech, Viksnins Harris & Padys PLLP, August 23, 2011: US08003651 (22 worldwide citation)

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for ...


3
Rod Duncan, Joel Witt, Mark Quadling, Henley Quadling, Jeffrey Prince, Branko Bem, Rui Xu, Kirk Ray, Basil Haymann, Anthony Starfield: Milling machine. D4D Technologies, David H Judson, June 5, 2007: US07226338 (12 worldwide citation)

The improved milling machine makes use of individually controlled x-axis, y-axis, and z-axis carriages. These carriages provide positive and precise control of the position of the cutting tools and the blank to be cut. A tool changer allows the tools to be changed to accommodate other materials. A c ...


4
Christian Holenstein, Aleksandar Miodrag Tasic, Li Chung Chang, Allen He, Rui Xu, Ehab Ahmed Sobhy Abdel Ghany, Wingching Vincent Leung, Ahmed Abdel Monem Youssef, Sang Hyun Woo: Single-input multiple-output amplifiers with independent gain control per output. QUALCOMM Incorporated, Toler Law Group PC, December 2, 2014: US08903343 (8 worldwide citation)

Amplifiers with multiple outputs and separate gain control per output are disclosed. In an exemplary design, an apparatus (e.g., a wireless device or an integrated circuit) may include first and second amplifier circuits. The first amplifier circuit may receive and amplify an input radio frequency ( ...


5
Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Birong Zhang, Christine Chabot, Steven Do: Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array Biopharma, Genentech, Viksnins Harris & Padys PLLP, October 7, 2014: US08853199 (7 worldwide citation)

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatmen ...


6
Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Jun Li, Christine Chabot: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Genentech, Viksnins Harris & Padys PLLP, September 30, 2014: US08846681 (7 worldwide citation)

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for ...


7
Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik: Dihydrofuro pyrimidines as AKT protein kinase inhibitors. Array Biopharma, Viksnins Harris & Padys PLLP, December 11, 2012: US08329701 (5 worldwide citation)

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hy ...


8
Anna L Banka, James F Blake, Josef R Bencsik, Kin Chiu Fong, Martin F Hentemann, Douglas M Sammond, Ian S Mitchell, Rui Xu, Eli M Wallace, Tony Tang: Pyrimidyl cyclopentanes as Akt protein kinase inhibitors. Array Biopharma, Viksnins Harris & Padys PLLP, December 4, 2012: US08324221 (5 worldwide citation)

The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitor ...


9
Josef R Bencsik, James F Blake, Nicholas C Kallan, Ian S Mitchell, Keith L Spencer, Dengming Xiao, Rui Xu, Christine Chabot, Jun Liang, Brian S Safina: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Genentech, Viksnins Harris & Padys PLLP, February 19, 2013: US08377937 (4 worldwide citation)

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for ...


10
Anna L Banka, Josef R Bencsik, James Blake, Martin Hentemann, Nicholas C Kallan, Jun Liang, Ian S Mitchell, Stephen T Schlachter, Eli M Wallace, Rui Xu, Tony P Tang: 5H-cyclopenta[D]pyrimidines as AKT protein kinase inhibitors. Genentech, Array BioPharma, Viksnins Harris & Padys PLLP, December 11, 2012: US08329709 (4 worldwide citation)

Compounds of Formula I are useful for inhibiting AKT protein kinases. Methods using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathol ...



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