1
Joel B Portnoff, Royden M Coe, John Grimm, Kenneth Raines, Joel Bartholomew: Formulation preparation device. The Liposome Company, B Braun Medical, Kenneth B Rubin, December 10, 1996: US05583052 (34 worldwide citation)

A formulation preparation device is provided herein which contains a valve assembly, transfer spikes, syringe port and tube, these components being interconnected so as to provide for controlled fluid flow between the spikes and port, through the assembly, in specific directions only. The device has ...


2
Royden M Coe, Laura Edgerly Pflug, Lawrence Boni, Joel Portnoff, Sharma R Minchey: Method of producing liposomes. The Liposome Company, Kenneth B Rubin, July 30, 1996: US05540936 (21 worldwide citation)

This invention provides a process for the production of liposomes by combining an organic phase and an aqueous at a volume ratio of less than 3:1; the process can be conducted under conditions which obtain a single-modal population distribution of liposomes encompassing a pre-selected mean particle ...


3
Royden M Coe, Robert L Thies, Joel B Portnoff: Liposome extrusion process. Burns Doane Swecker & Mathis, September 23, 2003: US06623671 (14 worldwide citation)

A method of sizing liposomes by passing a suspension of liposomes through an aluminum oxide porous film by entering the film via the smaller pores and extruded via the larger pores, under pressure, is disclosed. In a preferred embodiment, the porous film is a branched-pore type anodic aluminum oxide ...


4
Royden M Coe, Robert L Thies, Joel B Portnoff: Liposome extrusion process. Teresa Stanek Rea, Burns Doane Swecker & Mathis, May 2, 2002: US20020050660-A1

A method of sizing liposomes by passing a suspension of liposomes through an aluminum oxide porous film under pressure is disclosed. In a preferred embodiment, the porous film is a branched-pore type anodic aluminum oxide porous film. The process produces a population of liposomes substantially free ...