1
Ross A Tubo, Leesa M Barone, Courtney A Wrenn: Methods and compositions for the repair of articular cartilage defects in mammals. Genzyme Corporation, July 28, 1998: US05786217 (358 worldwide citation)

Provided are methods and compositions for the repair of articular cartilage defects in a mammal. Denuded chondrogenic cells are proliferated ex vivo as monolayer cultures in order to expand the pool of available chondrogenic cells. During proliferation the chondrogenic cells stop secreting the extra ...


2
Ross A Tubo, Leesa M Barone, Courtney A Wrenn: Methods and compositions for the repair of articular cartilage defects in mammals. Genzyme Corporation, March 3, 1998: US05723331 (244 worldwide citation)

Provided are methods and compositions for the repair of articular cartilage defects in a mammal. Denuded chondrogenic cells are proliferated ex vivo as monolayer cultures in order to expand the pool of available chondrogenic cells. During proliferation the chondrogenic cells stop secreting the extra ...


3
Ross A Tubo, Susan F Schaeffer, Alexander Schermer, Richard Odessey: Cryopreservation of cultured epithelial sheets. BioSurface Technology, Testa Hurwitz & Thibeault, September 8, 1992: US05145770 (33 worldwide citation)

Disclosed is a method of cryopreserving a sheet of living, cultured epithelial cells for use as a skin wound dressing. The method ensures that the integrity of the sheet will be maintained, and it preserves a significant number of cells in a mitotically competent, physiologically healthy form. It in ...


4
Ross A Tubo, Richard Odessey: Container for storage and distribution of a skin wound dressing. Biosurface Technology, Testa Hurwitz & Thibeault, August 20, 1991: US05040677 (9 worldwide citation)

Disclosed is a container for the storage and distribution of a cultured epithelial, generally planar, living, skin wound dressing that allows the dressing to be gently removed by lifting perpendicular to a support surface in the container. The design minimizes handling of the graft dressing thereby ...


5
Richard Odessey, Alexander Schermer, Susan F Schaeffer, Ross A Tubo: Cool storage of cultured epithelial sheets. Biosurface Technology, Testa Hurwitz & Thibeault, March 31, 1992: US05100676 (3 worldwide citation)

The viability of cohesive sheets of cultured epithelial cells such as keratinocytes used as wound dressings is maintained or improved by storage at a temperature within the range of 8.degree.-25.degree. C., preferably 13.degree.-23.degree. C., for periods greater than 8 hours, preferably up to 26 ho ...


6
Ross A Tubo, Susan F Shafer, Alexander Shermer, Richard Odyssei: Cryopreservation of cultured epithelial cell sheet. Biosurface Technol, April 28, 1997: JP1997-110601

PROBLEM TO BE SOLVED: To enable utilization as skin wound bandage having survivability and colony-forming ability of a cell by treating a culturing sheet of epithelial cell cooled to a specific temperature or below and impregnating a cryoprotecting agent therein. SOLUTION: A culturing sheet of epith ...