1
Donald G Wallace, Thomas L Smestad, John M McPherson, Karl A Piez, Saeid Seyedin, Rosa Armstrong: Methods of bone repair using collagen. Collagen Corporation, Ciotti & Murashige Irell & Manella, December 6, 1988: US04789663 (186 worldwide citation)

A method of repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or mixtures thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may also be ly ...


2
Steven W Adams, Rosa Armstrong, David Rosen: Bone growth factors and inhibitors of bone resorption for promoting bone formation. Celtrix Pharmaceuticals, Morrison & Foerster, June 2, 1992: US05118667 (157 worldwide citation)

Bone growth factors are used to stimulate new bone formation when administered with agents that inhibit bone resorption. These therapeutic combinations result in an enhanced rate of bone formation with an increase in bone mass.


3
Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong: Polypeptide cartilage-inducing factors found in bone. Collagen Corporation, Ciotti & Murashige Irell & Manella, September 27, 1988: US04774322 (131 worldwide citation)

Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. ...


4
Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong: Polypeptide cartilage-inducing factors found in bone. Collagen Corporation, Irell & Manella, June 27, 1989: US04843063 (110 worldwide citation)

Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. ...


5
Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong: Polypeptide cartilage-inducing factors found in bone. Collagen Corporation, Ciotti & Murashige Irell & Manella, March 7, 1989: US04810691 (97 worldwide citation)

Two proteins that are found is bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. ...


6
Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong: Polypeptide cartilage-inducing factors found in bone used in tissue proliferation. Collagen Corporation, Ciotti Murashige Irell & Manella, September 27, 1988: US04774228 (96 worldwide citation)

Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. ...


7
Hanne Bentz, Andrea Y Thompson, Rosa Armstrong, David M Rosen: Use of bone morphogenetic protein in synergistic combination with TGF-.beta. for bone repair. Celtrix Pharmaceuticals, Morrison & Foerster, February 28, 1995: US05393739 (73 worldwide citation)

Bone morphogenetic proteins -2 and -3 (BMPs -2 and -3) work in synergistic combination with TGF-.beta.z to provide compositions with increased osteogenic activity. Methods of treating bone defects, inducing bone growth and increasing bone marrow cell production using these compositions are also disc ...


8
George H Chu, Rosa Armstrong, Robert Chang: Method for improving implant fixation. Collagen Corporation, Morrison & Foerster, May 4, 1993: US05207710 (72 worldwide citation)

Stress-bearing prostheses for replacement or partial replacement of stress-bearing bone are fixed in place by bony ingrowth by providing a stress-bearing member having a porous region in combination with an osteogenic factor extract or a purified osteogenic inductive protein, optionally in combinati ...


9
George H Chu, Rosa Armstrong, Robert Chang: Implant fixation. Collagen Corporation, Irell & Manella, April 28, 1992: US05108436 (55 worldwide citation)

Stress-bearing prostheses for replacement or partial replacement of stress-bearing bone are fixed in place by bony ingrowth by providing a stress-bearing member having a porous region in combination with an osteogenic factor extract or a purified osteogenic inductive protein, optionally in combinati ...


10
Yasushi Ogawa, David K Schmidt, Rosa Armstrong, Ranga Nathan, Andrea Y Thompson, Saeid M Seyedin: Method for inducing bone growth. Celtrix Pharmaceuticals, Morrison & Foerster, May 4, 1993: US05208219 (50 worldwide citation)

Activin is administered systemically and locally to induce the growth of mature bone. Activin enhances the level of bone formation and the quality of the bone formed when administered locally with BMP or bone marrow. Administration of activin by subcutaneous route promotes systemic increase in the b ...