1
Thomas D Willis, Paul Hardenbol, Maneesh Jain, Viktor Stolc, Mostafa Ronaghi, Ronald W Davis: Direct multiplex characterization of genomic DNA. The Board of Trustees of the Leland Stanford Junior University, Fish & Neave, Daniel M Becker, February 22, 2005: US06858412 (151 worldwide citation)

The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.


2
Macdonald S Morris, Daniel D Shoemaker, Ronald W Davis, Michael P Mittmann: Selecting tag nucleic acids. Affymetrix, Morgan Lewis & Bockius, October 1, 2002: US06458530 (88 worldwide citation)

Methods of selecting tag nucleic acids and VLSIPS™ arrays and the arrays made by the methods are used to label and track compositions, including cells and viruses, e.g., in libraries of cells or viruses. In addition to providing a way of tracking compositions in mixtures, the tags facilitate analysi ...


3
Ronald W Davis, Arthur Myles: Method for detecting a nucleotide at a specific location within a nucleic acid using exonuclease activity. Collaborative Research, Wolf Greenfield & Sacks, February 21, 1995: US05391480 (73 worldwide citation)

A novel technique for determining the existence or nonexistence of a test nucleotide on a strand of DNA is provided. The determination advantageously uses an exonucleolytic agent that is capable of retaining a labeled nucleotide in a primer if there is a match between the test nucleotide on the stra ...


4
Barry R Bloom, Ronald W Davis, William R Jacobs Jr, Richard A Young, Robert N Husson: Recombinant mycobacterial vaccine. Albert Einstein College of Medicine of Yeshiva University, The Board of Trustees of the Leland Stanford Jr University, Whitehead Institute for Biomedical Research, Hamilton Brook Smith & Reynolds, April 2, 1996: US05504005 (57 worldwide citation)

Recombinant mycobacterial vaccine vehicles capable of expressing DNA of interest which encodes at least one protein antigen for at least one pathogen against which an immune response is desired and which can be incorporated into the mycobacteria or stably integrated into the mycobacterial genome. Th ...


5
Thomas D Willis, Paul Hardenbol, Maneesh Jain, Viktor Stolc, Mostafa Ronaghi, Ronald W Davis: Method for detecting and amplifying target DNA. The Board of Trustees of the Leland Stanford Junior University, Lisa M Treannie Esq, Morse Barnes Brown & Pendleton P C, April 20, 2010: US07700323 (45 worldwide citation)

The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.


6
Nader Pourmand, Ronald W Davis, Miloslav Karhanek: Charge perturbation detection system for DNA and other molecules. The Board of Trustees of the Leland Stanford Junior University, David J Aston, Peters Verny, August 31, 2010: US07785785 (39 worldwide citation)

Methods and apparatus for direct detection of chemical reactions are provided. In a preferred embodiment, electric charge perturbations of the local environment during enzyme-catalyzed reactions are sensed by an electrode system with an immobilized target molecule. The target molecule is preferably ...


7
David Botstein, Ronald W Davis, Gerald R Fink, Alison Taunton Rigby, Robert G Knowlton, Jen i Mao, Donald T Moir, Christopher G Goff: GAL1 yeast promoter linked to non galactokinase gene. Collaborative Research, Wolf Greenfield & Sacks, April 28, 1987: US04661454 (39 worldwide citation)

A DNA segment containing a GAL1 promoter linked to a gene other than the galactokinase gene for directing the expression of the gene within a yeast cell.


8
Ravi Kapur, Mehmet Toner, Roland Stoughton, Daniel Shoemaker, Ronald W Davis: Methods for the diagnosis of fetal abnormalities. The General Hospital Corporation, GPB Scientific, Verinata Health, Fish & Richardson P C, March 20, 2012: US08137912 (36 worldwide citation)

The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus b ...


9
Ronald W Davis, Richard A Young: System for efficient isolation of genes using probes. The Board of Trustees of the Leland Stanford Jr University, Bertram I Rowland, November 29, 1988: US04788135 (34 worldwide citation)

Systems are provided for the dual purpose of cloning genes using antibodies as probes and isolating unknown proteins encoded by cloned DNA. The method employs a vector derived from phage which is used in combination with a high frequency lysogenic host. The vector is further characterized by having ...


10
David Botstein, Ronald W Davis, Gerald R Fink, Alison Taunton Rigby, Robert G Knowlton, Jen i Mao, Donald T Moir, Christopher G Goff: Use of the GAL1 yeast promoter. Collaborative Research, Wolf Greenfield & Sacks, August 18, 1992: US05139936 (31 worldwide citation)

A DNA segment contains a GAL1 promoter of Saccharomyces cerevisae linked to a gene other than the galoctokinase gene, for directing the expression of the gene within a yeast cell.