1
Ronald P Haak, Felix Theeuwes, J Richard Gyory: Electrotransport transdermal system. Alza Corporation, D Byron Miller, Steven F Stone, Edward L Mandell, May 22, 1990: US04927408 (153 worldwide citation)

A transdermal therapeutic system which utilizes electrical current to facilitate agent delivery and which isolates the electrochemical reactants and products from the agent containing reservoir.


2
Robert M Myers, Ronald P Haak, Richard W Plue: Iontophoretic drug delivery apparatus. Alza Corporation, Grady J Stroud Stroud Willink Thompson & Howard Frenchick, November 14, 1995: US05466217 (111 worldwide citation)

An iontophoretic agent delivery device having a simplified structure and ease of manufacture. The device utilizes an electrical pathway comprising a source of electrical energy and an output means. The electrical pathway is disposed upon one of the two sides of a flexible, non-conductive substrate ( ...


3
Felix Theeuwes, J Richard Gyory, Ronald P Haak: Layered electrotransport drug delivery system. ALZA Corporation, Robert Scott Meece, D Byron Miller, Steven F Stone, March 29, 1994: US05298017 (100 worldwide citation)

An iontophoretic agent delivery device, having a layered structure and peripheral insulation, wherein ion transport occurs through two opposing surfaces of said device. The device is especially suited to agent delivery through body surfaces exposed to body fluids. A method of delivering an agent thr ...


4
Michel J N Cormier, James A Matriano, Ronald P Haak, Peter E Daddona: Reduction of skin sensitization in electrotransport drug delivery. Alza Corporation, Owen J Bates, D Byron Miller, Steven F Stone, November 30, 1999: US05995869 (87 worldwide citation)

A device and method are provided for reducing or preventing skin sensitization in electrotransport drug delivery. The method involves co-administration of a countersensitizing agent, comprising cis-urocanic acid or an analog thereof, with the drug delivered via electrotransport. Novel drug reservoir ...


5
Ronald P Haak, J Richard Gyory, Felix Theeuwes, Felix A Landrau, Nathan Roth, Robert M Myers: Iontophoretic delivery device and method of hydrating same. Alza Corporation, D Byron Miller, Edward L Mandell, Steven F Stone, October 27, 1992: US05158537 (87 worldwide citation)

A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules withi ...


6
J Richard Gyory, Ronald P Haak, Felix Theeuwes: Control membrane for electrotransport drug delivery. ALZA Corporation, D Byron Miller, Edward L Mandell, Steven F Stone, December 8, 1992: US05169383 (86 worldwide citation)

A membrane capable of controlling the rate at which an agent is released from an iontophoretic delivery device is provided. The membrane inhibits agent release from the delivery device when no electrical current is flowing and yet provides minimal impedance to electrically-assisted agent delivery. T ...


7
Ronald P Haak, Felix Theeuwes, J Richard Gyory: Transdermal delivery device. ALZA Corporation, D Byron Miller, Edward L Mandell, Steven F Stone, April 20, 1993: US05203768 (86 worldwide citation)

A transdermal drug delivery device (20) is provided having both an active drug reservoir (24) and a passive drug reservoir (26). Drug is actively delivered by iontophoresis from the active drug reservoir (24) by an electric field generated by a power source (21). Simultaneously, drug is delivered fr ...


8
Robert M Myers, Ronald P Haak, Richard W Plue: Iontophoretic drug delivery apparatus. Alza Corporation, Grady J Frenchick, May 17, 1994: US05312326 (82 worldwide citation)

An iontophoretic agent delivery device having a simplified structure and ease of manufacture. The device utilizes an electrical pathway comprising a source of electrical energy and an output means. The electrical pathway is disposed upon one of the two sides of a flexible, non-conductive substrate ( ...


9
Felix Theeuwes, J Richard Gyory, Ronald P Haak: Membrane for electrotransport transdermal drug delivery. Alza Corporation, D Byron Miller, Edward L Mandell, Steven F Stone, January 14, 1992: US05080646 (70 worldwide citation)

A membrane capable of inhibiting agent release from a delivery system when no electrical current is flowing and yet provide minimal impedance to electrically-assisted agent delivery, useful both for incorporating into electrotransport agent delivery systems and for use in measuring agent release rat ...


10
J Bradley Phipps, Gary A Lattin, Ronald P Haak, Suneel Gupta, Felix Theeuwes: Electrotransport agent delivery method and apparatus. Alza Corporation, Grady J Michael Best & Friedrich Frenchick, November 9, 1999: US05983130 (69 worldwide citation)

An electrotransport agent delivery device for delivering a therapeutic agent through a body surface, and a method for increasing agent delivery efficiency, is provided. The device includes a current controller which delivers a pulsating electrotransport current and peak current density I.sub.max, I. ...