1
Ronald Kluger, Jolanta Wodzinska: Specifically .beta.-.beta. cross-linked hemoglobins and method of preparation. The University of Toronto Innovations Foundation, Bereskin & Parr, October 5, 1993: US05250665 (36 worldwide citation)

A modified hemoglobin comprising hemoglobin which is cross-linked with a cross-linking reagent. The cross-linking reagent is selected such that the .beta.-chains are cross-linked within the 2,3-diphosphoglycerate binding site and the linkage distance between the .beta.-chains is between about 5 to 9 ...


2
Ronald Kluger, Mortimer Mamelak: Pharmaceutical composition and treatment. The University of Toronto Innovations Foundations, Lyon & Lyon, April 19, 1988: US04738985 (25 worldwide citation)

Sleep disorders in mammals, such as insomnia and narcolepsy, are treated by administering an effective amount of ethyl 4-acetoxybutanoate, or a closely related homolog thereof. The compounds may also be administered to mammals to cause muscle relaxation and as animal anaesthetics. Moreover the compo ...


3
Ronald Kluger, Yonghong Song: Specifically crosslinked hemoglobin with free functionality. March 21, 1995: US05399671 (5 worldwide citation)

Hemoglobin is site-specifically crosslinked into its tetrameric form by reaction with a trifunctional reagent which combines electrostatic effects, steric effects and the presence of functional groups so that two of the functional groups react with specific sites on the hemoglobin whilst the third s ...


4
Ronald Kluger, Mortimer Mamelak: Treatment of sleep disorders. University of Toronto Innovations Foundation, Lyon & Lyon, July 8, 1986: US04599355 (3 worldwide citation)

Sleep disorders in mammals, such as insomnia and narcolepsy, are treated by administering an effective amount of ethyl 4-acetoxybutanoate, or a closely related homolog thereof.


5
Ronald Kluger, Dongxin Hu: Cross-linking reagents for hemoglobin and hemoglobin products cross-linked therewith. Burns & Levinson, June 21, 2007: US20070142626-A1

A process for efficiently preparing bis-tetrameric hemoglobin in which the tetramers are specifically linked at predetermined sites on the β-sub-units and in which the tetramers themselves are effectively bonded to prevent dissociation into dimeric αβ-hemoglobin sub-units therefrom is provided. The ...


6
Ronald Kluger, Yonghong Song: Monooxygenase-like activity of heme proteins. University of Toronto Innovations Foundation, Ridout & Maybe, November 8, 1994: US05362856

Oxidation of C--H bonds in organic chemical compounds to C--OH bonds is accomplished by utilizing, as a monooxygenase, a heme protein such as methemoglobin or metmyoglobin in the presence of sulfate ion, in an aqueous medium.