1
John D Baldeschwieler, Ronald C Gamble, Marcia R Mauk: Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species. California Institute of Technology, Joseph E Mueth, January 12, 1982: US04310506 (131 worldwide citation)

Unilamellar vesicles comprising a lipid bilayer, an ionophore being incorporated in said lipid bilayer, a chelating agent entrapped within the vesicles, and an effective amount of physiologically compatible cation bound to said chelating agent within the vesicles. Unilamellar vesicles are loaded by ...


2
John D Baldeschwieler, Ronald C Gamble, Marcia R Mauk, Tsung Ying Shen, Mitree M Ponpipom: Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances. California Institute of Technology, Joseph E Mueth, January 12, 1982: US04310505 (105 worldwide citation)

Lipid vesicles comprising a lipid bilayer which includes analogs of cell-surface receptors such as dicetyl phosphate; stearylamine; 6-(5-cholesten-3.beta.-yloxy) hexyl 1-thio-.beta.-L-fucopyranoside; 6-(5-cholesten-3.beta.-yloxy) hexyl 1-thio-.beta.-D-galactopyranoside; 6-(5-cholesten-3.beta.-yloxy) ...


3
Ronald C Gamble, Paul G Schmidt: Contrast agents for NMR imaging. Vestar, Lyon & Lyon, March 1, 1988: US04728575 (101 worldwide citation)

An agent for contrast enhancement in nuclear magnetic resonance imaging is disclosed. Micellular particles such as phospholipid vesicles are associated with or enclose a paramagnetic material. The particles may be formulated with an agent, such as cholestrol, to promote vesicle stability and water e ...


4
Ronald C Gamble, Thomas P Theriault, John Baldeschwieler: Jet droplet device. Incyte Pharmaceuticals, Incyte Pharmaceuticals, December 14, 1999: US06001309 (71 worldwide citation)

Devices and methods are provided for precise reduction of arrays of microspots. A pulse jetting device is employed having a capillary of micron dimensions, with a portion of the capillary proximal to the jetting orifice circumferentially surrounded by a piezoelectric transducer. By appropriate desig ...


5
Ronald C Gamble, Thomas P Theriault, John D Baldeschwieler: Apparatus for the chemical synthesis of molecular arrays. Incyte Pharmaceuticals, Incyte Pharamaceuticals, November 9, 1999: US05981733 (61 worldwide citation)

An apparatus for the automated synthesis of molecular arrays. A jetting device is employed along with a reaction chamber to dispense reagents used in the synthesis onto the substrate. A positioning system moves the substrate from the jet to the reaction chamber. A controller controls the movement of ...


6
Ronald C Gamble, Thomas P Theriault, John Baldeschwieler: Jet droplet device. Incyte Pharmaceuticals, Incyte Pharmaceuticals, September 28, 1999: US05958342 (56 worldwide citation)

Devices and methods are provided for precise production of arrays of microspots. A pulse jetting device is employed having a capillary of micron dimensions, with a portion of the capillary proximal to the jetting orifice circumferentially surrounded by a piezoelectric transducer. By appropriate desi ...


7
John D Baldeschwieler, Ronald C Gamble, Thomas P Theriault: Method and substrate for performing multiple sequential reactions on a matrix. California Institute of Technology, Swanson & Bratschun, January 18, 2000: US06015880 (56 worldwide citation)

A method and apparatus are provided for preparing a substrate upon which is located microdrop-sized loci at which chemical compounds are synthesized or diagnostic tests are conducted. The loci are formed by applying microdrops from a dispenser from which a microdrop is pulse fed onto the surface of ...


8
Ronald C Gamble: Method for preparing small vesicles using microemulsification. Vestar Research, Lyon & Lyon, June 28, 1988: US04753788 (44 worldwide citation)

A method is provided for preparing small (less than 2000 .ANG.) lipid vesicles in commercial quantities by microemulsifying lipid compositions using very high shear forces generated in a homogenizing apparatus operated at high pressures at a selected temperature. These vesicles are suitable for vari ...


9
Ronald C Gamble, Paul E West, Marc R Schuman: Synchronous sampling scanning force microscope. Topometrix Corporation, Fulwider Patton Lee & Utecht, April 18, 1995: US05406832 (42 worldwide citation)

The synchronous sampling scanning force microscope includes a reflective cantilever arm having a free end which is oscillated at a frequency different from the resonance frequency of the cantilever arm. The motion of the oscillating cantilever arm is measured, to generate a deflection signal indicat ...


10
Ronald C Gamble, Micheal C Hair, Sava R Lukac, Michael G Taylor: Vesicle ink compositions. Xerox Corporation, Vestar, Lyon & Lyon, November 8, 1988: US04783220 (42 worldwide citation)

Ink compositions consisting of small unilamellar or multilamellar vesicles formed from surfactants of anionic, cationic, zwitterionic and nonionic molecules having an oil soluble dye, inclusive of a lipid-soluble dye associated therewith are described. The dye to surfactant ratio is preferably from ...