1
Shmuel Cabilly, Herbert L Heyneker, William E Holmes, Arthur D Riggs, Ronald B Wetzel: Recombinant immunoglobin preparations. Genentech, March 28, 1989: US04816567 (2766 worldwide citation)

Altered and native immunoglobulins, including constant-variable region chimeras, are prepared in recombinant cell culture. The immunoglobulins contain variable regions which are immunologically capable of binding predetermined antigens. Methods are provided for refolding directly expressed immunoglo ...


2
Shmuel Cabilly, Herbert L Heyneker, William E Holmes, Arthur D Riggs, Ronald B Wetzel: Methods of producing immunoglobulins, vectors and transformed host cells for use therein. Genentech, Burns Doane Swecker & Mathis, December 18, 2001: US06331415 (344 worldwide citation)

The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce both the heavy and light chains o ...


3
Ronald B Wetzel: Purification and activity assurance of precipitated heterologous proteins. Genentech, July 8, 1986: US04599197 (27 worldwide citation)

A heterologous expression product in host cells is separated from the host cell material by suspending the material in a buffered solution, disrupting the cells and separating the product as refractile material. The refractile material can be dissolved in a strongly denaturing solution, which is the ...


4
Shmuel Cabilly, Herbert L Heyneker, William E Holmes, Arthur D Riggs, Ronald B Wetzel: Methods of making antibody heavy and light chains having specificity for a desired antigen. Genentech, City of Hope, Sidley Austin, April 12, 2011: US07923221 (6 worldwide citation)

The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce both the heavy and light chains o ...


5
Ronald B Wetzel: Stabilized A-beta protofibrillar aggregates. Fenwick & West, April 13, 2006: US20060079447-A1

Described and claimed herein are methods for producing chemically stabilized Aβ protofibrillar aggregates, and compositions made therefrom. Compositions produced are useful in facilitating detailed studies of Aβ protofibril structure, fibril formation, and progression of Aβ related diseases, e.g., A ...