1
Charles D Kelman, Roman Perez Soler: Cryogenic surgical system and method of use in removal of tissue. Darby & Darby, March 4, 2003: US06527765 (122 worldwide citation)

The present invention is directed towards a surgical system and method of use for treating and removing unwanted tissue, preferably from an organ or other internal part of a patient. The system includes a cryosurgical component for first freezing the unwanted living tissue by forming an ice mass whi ...


2
Waldemar Priebe, Jonathan B Chaires, Teresa Przewloka, Izabela Fokt, Roman Perez Soler: Bis-anthracyclines with high activity against doxorubicin resistant tumors. Arnold White & Durkee, February 23, 1999: US05874412 (47 worldwide citation)

The present invention discloses new and novel bisanthracyclines linked through the saccharide portions. These compounds show high activity against two clinically relevant mechanisms of resistance. A novel approach of the invention produces compounds that are as active or more so than the parent comp ...


3
Kapil Mehta, Roman Perez Soler, Gabriel Lopez Berestein, Robert P Lenk, Alan C Hayman deceased: Formulation and use of carotenoids in treatment of cancer. Board of Regents the University of Texas, Aronex Pharmaceuticals, Arnold White & Durkee, September 22, 1998: US05811119 (33 worldwide citation)

A reduced-toxicity formulation of carotenoids is disclosed which is stable in an aqueous environment. The formulation includes a carotenoid, lipid carrier particles (such as liposomes), and an intercalation promoter agent (such as a triglyceride), which causes the carotenoid to be substantially unif ...


4
Abdul R Khokhar, Gabriel Lopez Berestein, Roman Perez Soler: Hydrophobic cis-platinum complexes efficiently incorporated into liposomes. The Board of Regents The University of Texas System, Arnold White & Durkee, January 12, 1993: US05178876 (25 worldwide citation)

The present invention involves the synthesis and use of new platinum compounds. These new platinum compounds are easy to encapsulate in liposomes at high efficiencies. They are further characterized as platinum (II) four coordinate complex having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are ...


5
Roman Perez Soler, Steven M Sugarman, Kenneth R Poirot: Lipid complexed topoisomerase I inhibitors. Roman Perez Soler, Steven M Sugarman, Kenneth R Poirot, Arnold White & Durkee, November 10, 1998: US05834012 (18 worldwide citation)

The present invention is described as a lipid-complexed topoisomerase I inhibitor (TII), for example camptothecin (CPT) preparation that allows for intravenous administration in vivo in clinically relevant lipid:drug ratios. The lipid formulation has in vitro antitumor activity similar to that of th ...


6
Roman Perez Soler, Waldemar Priebe, Gabriel Lopez Berestein: Liposome compositions of anthracycline derivatives. Board of Regents The University of Texas System, Arnold White & Durkee, September 5, 1989: US04863739 (15 worldwide citation)

Disclosed are liposomal antitumor compositions having improved pharmacological characteristics. Liposomes described herein are formed through the incorporation of a particular class of anthracyclines, the 4-demethoxy-3'-desamino-2'-iodo analogs, shown to have extremely high incorporatio efficiencies ...


7
Abdul R Khokhar, Gabriel Lopez Berestein, Roman Perez Soler: Hydrophobic cis-platinum complexes efficiently incorporated into liposomes. The Board of Regents The University of Texas System, Arnold White & Durkee, May 26, 1992: US05117022 (14 worldwide citation)

The present invention concerns a platinum (II) four-coordinant complex having the formula: ##STR1## wherein R.sub.1 is an alkyl diamine or cycloalkyl diamine and R.sub.2 and R.sub.3 are an alkylcarboxylato containing from five to ten carbon atoms. The R.sub.1 is preferably trans-D,L-1,2-diaminocyclo ...


8
Waldemar Priebe, Piotr Skibicki, Roman Perez Soler: Anthracyclines with unusually high activity against cells resistant to doxorubicin and its analogs. Waldemar Priebe, Piotr Skibicki, Roman Perez Soler, Arnold White & Durkee, April 29, 1997: US05625043 (11 worldwide citation)

The present disclosure details novel modified anthracyclines, the synthesis thereof, and their use in treating patients with tumors. Preferred aspects of the disclosure involve modified anthracyclines which have an O-substituted aromatic ring on their sugar moiety. Other preferred aspects of the dis ...


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Kapil Mehta, Roman Perez Soler, Gabriel Lopez Berestein, Robert Lenk, Alan C Hayman: Formulation and use of carotenoids in treatment of cancer. Board of Regents The University of Texas System, Aronex Pharmaceuticals, Fulbright & Jaworski L, March 13, 2001: US06200597 (7 worldwide citation)

A reduced-toxicity formulation of carotenoids is disclosed which is stable in an aqueous environment. The formulation includes a carotenoid, lipid arrier particles (such as liposomes), and an intercalation promoter agent (such as a triglyceride), which causes the carotenoid to be substantially unifo ...