1
Rolf Knobel: Analytical device for separating magnetic microparticles from suspensions. Hoffmann La Roche, George W Johnston, William H Epstein, John P Parise, January 6, 1998: US05705062 (105 worldwide citation)

An analytical device separates magnetic microparticles from a suspension. The separating portion of the device contains two permanent magnets between which the reaction vessel containing the suspension is disposed. For the purpose of more rapid, complete separation of the magnetic microparticles, ma ...


2
Rolf Knobel: Apparatus for suspending particles. Hoffmann La Roche, George M Gould, George W Johnston, John P Parise, January 9, 1996: US05482863 (18 worldwide citation)

An analytical device incorporating a system for suspending particles includes a conveying device for positioning a pipetting needle at a distance from the central longitudinal axis of the reaction vessel. Particles are suspended by delivering amounts of liquid reagent to two different positions at a ...


3
Rolf Knobel: Method for suspending particles. Hoffman La Roche, George M Gould, George W Johnston, John P Parise, January 9, 1996: US05482864 (17 worldwide citation)

An analytical device incorporating a system for suspending particles includes a conveying device for positioning a pipetting needle at a distance from the central longitudinal axis of the reaction vessel. Particles are suspended by delivering amounts of liquid reagent to two different positions at a ...


4
Renato Belz, Andreas Gisler, Robert Huesler, Rolf Knobel, Christian Thalmann: Method for separating and detecting an analyte. Roche Molecular Systems, M Reza Savari, July 2, 2013: US08476015 (1 worldwide citation)

A method for separating and analyzing an analyte is provided which comprises, in a first position, transferring a liquid sample to a multiwell plate with a pipette tip, replacing the tips in the tip rack in the same position, and re-using the pipette tips for aspirating and dispensing liquid.


5
Ronald T Kurnik, Laurent Francioli, Rolf Knobel: PCR elbow determination by use of a double sigmoid function curve fit with the Levenburg-Marquardt algorithm and normalization. Roche Molecular Systems, Townsend and Townsend and Crew, Gerald T Gray, March 16, 2010: US07680868 (1 worldwide citation)

Systems and methods for determining characteristic transition values such as elbow values in sigmoid or growth-type curves, such as the cycle threshold (Ct) value in PCR amplification curves. A double sigmoid function with parameters determined by a Levenberg-Marquardt (LM) regression process is use ...


6
Ronald T Kurnik, Laurent Francioli, Rolf Knobel: Levenberg-Marquardt outlier spike removal method. Roche Molecular Systems, Townsend and Townsend and Crew, Gerald T Gray, February 23, 2010: US07668663 (1 worldwide citation)

Systems and methods for identifying and removing spikes in data sets representing PCR growth curves or other sigmoid type curves or growth curves. A double sigmoid function with parameters determined using a Levenberg-Marquardt regression algorithm is used to find an approximation to the curve, and ...


7
Andreas Gisler, Robert Huesler, Rolf Knobel: Workflow timing between modules. Roche Molecular Systems, David J Chang, M Reza Savari, May 19, 2015: US09034575 (1 worldwide citation)

The invention relates to a method of isolating and analyzing an analyte using an analytical apparatus which comprises modules of different types, wherein any one module of one type has a specific, pre-defined timing for carrying out its workflow.


8
Paul Frank, Andreas Gisler, Robert Huesler, Rolf Knobel, Siegfried Mueller, Urs Schnieper, Heinz Trueeb: Sample distribution in an analytical system for processing an analyte. Roche Molecular Systems, Pamela C Aucona, David J Chang, July 5, 2016: US09383378

A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional n×m arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel ...


9
Paul Frank, Andreas Gisler, Robert Huesler, Rolf Knobel, Siegfried Mueller, Urs Schnieper, Heinz Trueeb: Sample distribution in a method for isolating analytes in fluid samples in an automated system. ROCHE MOLECULAR SYSTEMS, Pamela C Ancona, David J Chang, July 5, 2016: US09383379

A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional n×m arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel ...


10
Renato Belz, Andreas Gisler, Robert Huesler, Rolf Knobel, Christian Thalmann: Method for separating and detecting an analyte. ROCHE MOLECULAR SYSTEMS, M Reza Savari, April 19, 2016: US09315801

A method for separating and analyzing an analyte is provided which comprises, in a first position, transferring a liquid sample to a multiwell plate with a pipette tip, replacing the tips in the tip rack in the same position, and re-using the pipette tips for aspirating and dispensing liquid.