1
Roger N Piasio, James W Ryan, James E Woiszwillo: Reverse sandwich immunoassay. Corning Glass Works, William E Maycock, Clinton S Janes Jr, Clarence R Patty Jr, July 4, 1978: US04098876 (355 worldwide citation)

Method of determining the presence and/or concentration of a polyvalent antigenic substance in a fluid. The method comprises the steps of incubating the fluid with labeled antibodies to the substance to form a first labeled immunochemical complex and then incubating that complex with immobilized ant ...


2
Howard M Chandler, Roger N Piasio, Karen Prouty: Immunochromatographic assay device. SmithKline Diagnostics, William H May, P R Merchant & Gould Harder, March 2, 1999: US05877028 (63 worldwide citation)

A chromatographic assay device for use with immunoassays allows rapid and convenient assays of analytes of biological interest, and permits extractions to be carried out in situ, avoiding the use of separate extraction vessels. The device has a wide dynamic range and avoids interference from particu ...


3
Donald J Lennon, Roger N Piasio: Detachable-element assay device. William H May, P R Merchant & Gould Harder, August 17, 1999: US05939252 (46 worldwide citation)

An assay device for detection or determination of an analyte in a sample uses either removably attachable components or hinged panels to provide greater flexibility and reduce manufacturing and storage costs. In one embodiment of the device, the device comprises: (1) a first opposable component incl ...


4
Roger N Piasio, David A Perry, Pangal N Nayak: Method and apparatus for performing in vitro clinical diagnostic tests using a solid phase assay system. Ventrex Laboratories, Irons and Sears, September 30, 1980: US04225575 (41 worldwide citation)

A method and apparatus for conducting chemical reactions at a liquid-solid interface wherein a reaction component is fixed on the surface of a solid phase immersed in a liquid phase containing a freely diffusing, mobile reaction component. The apparatus comprises a substantially smooth-surfaced matr ...


5
Roger N Piasio, David A Perry, Pangal N Nayak: Method and apparatus for performing in nitro clinical diagnostic tests using a solid phase assay system having special utility for use with automatic pipetting equipment. Ventrex Laboratories, April 8, 1980: US04197287 (38 worldwide citation)

A method and solid phase matrix is disclosed which has special utility for use in conjunction with automatic pipetting apparatus for conducting reactions at a liquid-solid interface. A reaction component is fixed on the surface of the solid phase matrix which is wetted by a liquid phase containing a ...


6
Roger N Piasio, David A Perry, Pangal N Nayak: Method and apparatus for performing in vitro clinical diagnostic tests using a solid phase assay system. Ventrex Laboratories, December 15, 1981: US04305924 (38 worldwide citation)

An improved method for performing an in vitro diagnostic test is provided. The method utilizes a solid phase device having a fixed component immobilized on its surface which is in contact with a fluid sample when inserted therein. The improvement resides in utilizing a receptacle, into which the dev ...


7
Richard J Zahradnik, Roger N Piasio: Method and apparatus for performing multiple, simultaneous in vitro diagnostic tests using a solid phase system. Ventrex Laboratories, Irons & Sears, March 29, 1983: US04378344 (37 worldwide citation)

A method for performing multiple, simultaneous in vitro diagnostic tests is provided. The method utilizes a solid phase device comprising a receptacle and an insert. The receptacle has one or more fixed components immobilized on its inner surface. The insert has one or more fixed components--differe ...


8
Roger N Piasio, Nathan Turner: Process for (A) separating biological/ligands from dilute solutions and (B) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughtout. March 28, 2006: US07018849 (30 worldwide citation)

Superparamagnetic (“SPM”) subunits of 1–30 nm average mean diameter (e.g. ferro fluid) subparticles are treated with a magnetically noninterfering substance capable of coating and covering them (e.g, BSA) and they spontaneously form agglomerates of about 100 nm to about 450 nm or higher average mean ...


9
Roger N Piasio, Nathan Turner: Dry chemistry, lateral flow-reconstituted chromatographic enzyme-driven assays. Binax, Foley Hoag, September 16, 2008: US07425302 (18 worldwide citation)

A lateral flow chromatographic assay format for the performance of rapid enzyme-driven assays is described. A combination of components necessary to elicit a specific enzyme reaction, which are either absent from the intended sample or insufficiently present therein to permit completion of the desir ...


10
Roger N Piasio, Leslie Latt: Quantitative immunoassay for volatile organic compounds. Quantix Systems, Pennie & Edmonds, January 24, 1995: US05384262 (13 worldwide citation)

The invention pertains to an immunoassay method for determining the presence of volatile organic compounds in aqueous, soil and air samples by simultaneously collecting and testing a sample volume suspected to contain such organic compounds. As a major problem in the assay of such materials is their ...