1
Rodney W Stevens, Takashi Mano, Kazunari Nakao, Yoshiyuki Okumura: 5-lipoxygenase inhibitors. Pfizer, Peter C Richardson, Paul H Ginsburg, Garth Butterfield, March 16, 1999: US05883106 (27 worldwide citation)

Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: ##STR1## and the pharmaceutically acceptable salts thereof, wherein Ar.sup.1 is a heterocyclic moiety which is selected from imidazolyl, pyrrolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, indo ...


2
Yoshihiko Kitaura, Fumitaka Ito, Rodney W Stevens, Nobuko Asai: Antiallergy and antiinflammatory agents, compositions and use. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, July 30, 1991: US05036088 (19 worldwide citation)

Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R.sub.1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen, alkyl or alkanoyl and X is C.dbd.O, CH.sub.2, NH, O or S as anti ...


3
Rodney W Stevens, Hiromasa Morita, Masami Nakane: Indole derivatives as antiallergy and antiinflammatory agents. Pfizer, Peter C Richardson, Gregg C Benson, James T Jones, March 1, 1994: US05290788 (12 worldwide citation)

Alkoxy substituted indole derivatives as inhibitors of lipoxygenase and useful as antiallergy and antiinflammatory agents.


4
Masami Nakane, Rodney W Stevens: Benzimidazole compounds and their use. Pfizer, Peter C Richardson, J Trevor Lumb, Gregg C Benson, August 25, 1992: US05141950 (10 worldwide citation)

Certain benzimidazole compounds and their pharmaceutically acceptable salts, are dual inhibitors of lipoxygenase and cycylooxygenase enzymes, and so are useful as antiallergy and antiinflammatory agents.


5
Yoshihiko Kitaura, Fumitaka Ito, Rodney W Stevens, Nobuko Asai: Antiallergy and antiinflammatory agents. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, May 30, 1989: US04835166 (9 worldwide citation)

Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R.sub.1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen, alkyl or alkanoyl and X is C.dbd.O, CH.sub.2, NH, O or S as anti ...


6
Yoshihiko Kitaura, Fumitaka Ito, Rodney W Stevens, Nobuko Asai: Antiallergy and antiinflammatory agents. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, February 27, 1990: US04904685 (7 worldwide citation)

Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R.sub.1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen, alkyl or alkanoyl and X is C.dbd.O, CH.sub.2, NH, O or S as anti ...


7

8
Yoshihiko Kitaura, Fumitaka Ito, Rodney W Stevens, Nobuko Asai: Antiallergy and antiinflammatory agents. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, April 9, 1991: US05006541 (5 worldwide citation)

Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R.sub.1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R.sub.2 is hydrogen, alkyl or alkanoyl and X is C.dbd.O, CH.sub.2, NH, O or S as anti ...


9
Rodney W Stevens, Takafumi Ikeda, Hiroaki Wakabayashi, Masami Nakane: Antiinflammatory hydroxamic acids and N-hydroxyureas. Pfizer, Peter C Richardson, Gregg C Benson, D Stuart McFarlin, October 26, 1993: US05256789 (4 worldwide citation)

Compounds having the structure ##STR1## wherein X is nitrogen, oxygen, sulfur or a bond and Z is oxygen or sulfur have been synthesized. These compounds are lipoxygenase inhibitors and are useful as the active agent in pharmaceutical compositions for treating inflammatory conditions in humans and ot ...


10
Takafumi Ikeda, Akiyoshi Kawai, Takashi Mano, Yoshiyuki Okumura, Rodney W Stevens: Cyclopropyl N-hydroxyurea and N-hydroxyacetamides which inhibit lipoxygenase. Pfizer, Peter C Richardson, Paul H Ginsburg, Bryan C Zielinski, May 28, 1996: US05521212 (3 worldwide citation)

Compounds of the formula ##STR1## wherein A is C1 to C3 alkylene, Ar is phenyl or styryl, R is halosubstituted C1 to C3 alkyl, NHR' or ##STR2## R' is hydrogen or C2 to C8 alkytthioalkyl, n is an integer of from 1 to 4 and p is an integer of from 2 to 5, with the proviso that when R' is hydrogen then ...