1
Rodney C Schnur: Bicyclic ansamycins. Pfizer, Peter C Richardson, Paul H Ginsburg, Grover F Fuller Jr, February 7, 1995: US05387584 (48 worldwide citation)

This invention relates to compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and X are as defined below. Such compounds are useful as oncogene inhibitors and antitumor agents.


2
Rodney C Schnur: Hypoglycemic 5-substituted oxazolidine-2,4-diones. Pfizer, Charles J Knuth, Albert E Frost, Robert K Blackwood, January 4, 1983: US04367234 (27 worldwide citation)

Hypoglycemic 5-phenyl and 5-naphthyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.


3
Reinhard Sarges, John L Belletire, Rodney C Schnur: Pharmaceutical preparations containing coumarin carboxylic acid derivatives. Pfizer, F X Murphy, C J Knuth, A J Nelson, July 1, 1980: US04210667 (25 worldwide citation)

Preparations useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. The preparations contain substituted and unsubstituted coumarin-4-carboxylic or acetic acid derivatives as the active ingredients.


4
Rodney C Schnur: Hypoglycemic 5-substituted oxazolidine-2,4-diones. Pfizer, Charles J Knuth, Albert E Frost, Robert K Blackwood, August 3, 1982: US04342771 (23 worldwide citation)

Hypoglycemic 5-chromanyl, 2,3-dihydro-5-benzo[b]furanyl, 5-pyridyl, 5-quinolyl, 5-pyrrolyl, 5-indolyl, 5-thiazolyl, 5-oxazolyl, 5-isothiazolyl and 5-isoxazolyl oxazolidine-2,4-diones and the pharmaceutically acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyper ...


5
Rodney C Schnur: Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones. Pfizer, Charles J Knuth, Peter C Richardson, Robert F Sheyka, October 14, 1986: US04617312 (23 worldwide citation)

A series of 5-(2-alkoxyphenyl)thiazolidinediones and pharmaceutically acceptable salts thereof useful as hypoglycemic agents, aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications; intermediates therefore; and process for preparation of said compou ...


6
Reinhard Sarges, Rodney C Schnur: Thienohydantoin derivatives. Pfizer, Francis X Murphy, Charles J Knuth, Peter C Richardson, November 28, 1978: US04127665 (17 worldwide citation)

Novel spiro-thienohydantoin derivatives useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. Preferred compounds include 6,7-dihydro-spiro-[benzo(b)thiophene-4(5H),4'-imidazolidine]-2',5'-dione, 2-chloro-spiro-[cyclopenta( ...


7
Rodney C Schnur, Anton F J Fliri: Benzamide protease inhibitors. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, October 17, 1989: US04874864 (15 worldwide citation)

Compounds of the formula ##STR1## where HET is a heterocyclic group, n is an integer of 0 to 2 and R.sup.1 is hydrogen or lower alkyl are protease inhibitors use as anti-plasmin and anti-thrombin agents.


8
Rodney C Schnur: Spiro-oxazolidindiones. Pfizer, Francis X Murphy, Charles J Knuth, Peter C Richardson, April 29, 1980: US04200642 (15 worldwide citation)

Novel spiro-oxazolidindiones useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. Pharmaceutical compositions containing the novel compounds and a method of treating chronic diabetic complications are also disclosed.


9
Reinhard Sarges, Rodney C Schnur: Treating diabetes-associated complications with hydantoin amines. Pfizer, Francis X Murphy, Charles J Knuth, Peter C Richardson, February 3, 1981: US04248882 (14 worldwide citation)

A series of amino-and alkylamino-substituted spirohydantoins and pharmaceutically acceptable salts thereof useful as inhibitors of the enzyme aldose reductase and as therapeutic agents for the treatment of chronic complications associated with diabetes are disclosed. Preferred compounds include 6-ch ...


10
Rodney C Schnur, Anton F J Fliri: Benzamide protease inhibitors. Pfizer, Peter C Richardson, J Trevor Lumb, James M McManus, August 14, 1990: US04948891 (13 worldwide citation)

Compounds of the formula ##STR1## where Het is a heterocyclic group, n is an integer of 0 to 2 and R.sup.1 is hydrogen or lower alkyl are protease inhibitors useful as anti-plasmin and anti-thrombin agents.