1
Robert W Flower: Method and apparatus for the continuous monitoring of hemoglobin saturation in the blood of premature infants. The Johns Hopkins University, Robert E Archibald, Howard W Califano, December 4, 1984: US04485820 (82 worldwide citation)

A method and apparatus is disclosed for continuously monitoring hemoglobin saturation in the blood of premature infants. A substantial portion of the eye fundus is illuminated by passing at least two frequencies of light through the pupillary opening. The light scattered from the fundus is collected ...


2
John C Docherty, Mark Hewko, Gurpreet Mangat, Robert W Flower, Seshadri M Chari: Method and apparatus for performing intra-operative angiography. National Research Council of Canada, Kudirka & Jobse, July 5, 2005: US06915154 (73 worldwide citation)

Method for assessing the patency of a patient's blood vessel, advantageously during or after treatment of that vessel by an invasive procedure, comprising administering a fluorescent dye to the patient; obtaining at least one angiographic image of the vessel portion; and evaluating the at least one ...


3
Robert W Flower: Method and apparatus to identify and treat neovascular membranes in the eye. The Johns Hopkins University, Mary Louise Beall, January 18, 1994: US05279298 (67 worldwide citation)

The method and apparatus of the invention allow a neovascular membrane in the ocular vasculature of the fundus of the eye to be identified and treated while minimizing damage to the sensory retina. First a bolus of fluorescent dye is injected and allowed to circulate through the ocular vasculature. ...


4
Robert W Flower: Methods and apparatus for improved visualization of choroidal blood flow and aberrant vascular structures in the eye using fluorescent dye angiography. The Johns Hopkins University, Francis A Cooch, February 28, 1995: US05394199 (50 worldwide citation)

A method for visualizing the choriocapillaris of the eye in a sequence of ICG angiographic images comprising subtracting each image in the angiographic sequence from a succeeding image. In practice, a modified fundus camera is used to provide digitized images which are subtracted pixel by pixel. To ...


5
Robert W Flower, Abu Alam: Methods for diagnosing and treating conditions associated with abnormal vasculature using fluorescent dye angiography and dye-enhanced photocoagulation. Akorn, Leydig Voit & Mayer, February 26, 2002: US06351663 (42 worldwide citation)

Methods concerning medical uses for fluorescent dyes, e.g., Indocyanine green (ICG), fluorescein, rose bengal, for diagnosis and treatment. Methods for enhancing the clarity of fluorescent dye angiograms using relatively high dye concentrations, methods for determining the direction of blood flow wi ...


6
Robert W Flower, Abu Alam: Methods for treating conditions and illnesses associated with abnormal vasculature. Akorn, Leydig Voit & Mayer, September 3, 2002: US06443976 (40 worldwide citation)

Use of radiation-absorbing dyes (e.g., indocyanine green (ICG), fluorescein, rose bengal) and photodynamic dyes (e.g., hematoporphyrins, aminolevulinic acids, porphyrins, merocyanines, porphycenes, porfimer sodium, verteporfin, Photofrin II, PH-10, chlorins, zinc phthalocyanine, purpurins, pheophorb ...


7
Abu Alam, Ashok J Chavan, Robert W Flower: Indocyanine green (ICG) compositions and related methods of use. Akora, Leydig Voit & Mayer, September 13, 2005: US06944493 (13 worldwide citation)

Aqueous indocyanine green (ICG) composition exhibiting enhanced stability, as well as enhanced ICG concentration, as compared to presently available ICG products. The composition comprises an aqueous ICG composition comprising ICG at a concentration of at least about 10 mg/ml and an aqueous diluent, ...


8
John C Docherty, Mark Hewko, Gurpreet Mangat, Robert W Flower, Seshadri M Chari: Method and apparatus for performing intra-operative angiography. National Research Council of Canada, Rissman Hendricks & Oliverio, February 1, 2011: US07881777 (8 worldwide citation)

Method for assessing the patency of a patient's blood vessel, advantageously during or after treatment of that vessel by an invasive procedure, comprising administering a fluorescent dye to the patient; obtaining at least one angiographic image of the vessel portion; and evaluating the at least one ...


9
Robert W Flower: Imaging methods and compositions comprising fluorescent dyes associated with viral components for nerve imaging. Novadaq Technologies, Rissman Hendricks & Oliverio, January 29, 2013: US08361775 (5 worldwide citation)

Disclosed herein are compositions and methods for imaging nerve cells. The composition comprises a fluorescent dye; and a viral component selected from a neurotropic, replication-defective virus, a viral protein of a neurotropic virus, and a capsid of a neurotropic virus. Although the fluorescent dy ...


10
Robert W Flower: Methods for production and use of substance-loaded erythrocytes (S-IEs) for observation and treatment of microvascular hemodynamics. NOVADAQ TECHNOLOGIES ULC, Morrison & Foerster, August 7, 2018: US10041042

Disclosed herein are methods, kits, and compositions for medical imaging relating to fluorescent dyes entrapped in erythrocytes. Also disclosed therein are methods, and compositions further comprising erythrocytes entrapping at least one therapeutically active agent, as well as methods for releasing ...