1
Kurt T Kunas, Robert V Oakley, Fauad F Hasan, Michael E Goodwin, Jeremy K Larsen, Nephi D Jones: Stirred-tank reactor system. Baxter International, Baxter Healthcare, Paula J F Kelly, Bell Boyd & Lloyd, June 10, 2008: US07384783 (55 worldwide citation)

The present invention relates to a stirred-tank reactor system and methods of preparing such systems. The present invention further encompasses the use of the stirred-tank reactor system as a disposable bioreactor and in kits with disposable elements.


2
Derik R West, Whitt F Woods, Jeremy K Larsen, Nephi D Jones, Robert V Oakley, Kurt Thomas Kunas, Fauad F Hasan: Mixing systems and related mixers. HyClone Laboratories, Baxter International, Baxter Healthcare, Workman Nydegger, March 23, 2010: US07682067 (46 worldwide citation)

A mixing system includes a housing and a motor mount disposed on the housing and having a passage extending therethrough. A dive motor is coupled with the motor mount for selectively rotating the motor mount relative to the housing. A rotational assembly includes a hub having a passageway extending ...


3
Peter C Brown, Mark T Wininger, Robert V Oakley: Method for culturing animal cells. Baxter International, St Onge Steward Johnston & Reens, July 28, 1998: US05786215 (36 worldwide citation)

An apparatus and method for the in vitro culturing of animal cells, e.g., mammalian cells, to attain mass growth of the cells per se and/or to recover cell-secreted products of interest therefrom, in which an integral culture and gassing element is formed from spirally-wound or concentricallywrapped ...


4
Robert V Oakley: Apparatus and method for periodic aseptic withdrawal of liquid samples from a sterile liquid source. Baxter International, St Onge Steward Johnston & Reens, March 12, 1991: US04999307 (17 worldwide citation)

A liquid sampling device is provided for periodic aseptic removal of samples of a source liquid to be analyzed, comprised of a primary liquid conduit tube closed at one end and, at the other end, adapted to be in liquid communication with a principal or secondary flow line through which the source l ...


5
Robert V Oakley, Van Taiariol, Rudolpf F Bliem, James F Long: Apparatus for oxygenating culture medium. Bio Response, St Onge Steward Johnston & Reens, January 30, 1990: US04897359 (17 worldwide citation)

An oxygenator, particularly for proving oxygen and/or carbon dioxide or other gases to culture medium used in the in vitro culture of animal cells, comprised of a collection of elongate gas-permeable, liquid-impermeable tubes through which oxygen-containing gas flows and permeates through the tube w ...


6
Van Taiariol, Robert V Oakley, Peter Ventura: Method for in vitro reproduction and growth of cells in culture medium. Baxter International, St Onge Steward Johnston & Reens, May 21, 1991: US05017490 (16 worldwide citation)

Method and apparatus for in vitro culture of cells in culture medium to produce a viable cell mass of cell number greater than the initial cell number, wherein a cell mass of particular cell number is cultured in a first oxygen-permeable culture sub-compartment to an increased cell number, and then ...


7
Kurt T Kunas, Robert V Oakley, Fauad F Hasan, Michael E Goodwin, Jeremy K Larsen, Nephi D Jones: Probe connector assembly and method of use. HyClone Laboratories, Baxter International, Baxter Healthcare, Workman Nydegger, March 8, 2011: US07901934 (13 worldwide citation)

A probe assembly includes a tubular sleeve having a passage extending between a first end and an opposing second end. The tubular sleeve is movable between an extended position wherein the first end and the opposing second end are spaced apart and a collapsed position wherein the first end and the o ...


8
Kurt T Kunas, Robert V Oakley, Fauad F Hasan, Michael E Goodwin, Jeremy K Larsen, Nephi D Jones: Stirred tank reactor systems and methods of use. Hyclone Laboratories, Baxter International, Baxter Healthcare, Workman Nydegger, January 7, 2014: US08623640 (7 worldwide citation)

A reactor system includes a flexible bag having an interior surface bounding a compartment. An elongated tubular connector is disposed within the compartment of the flexible bag, the tubular connector having a first end and an opposing second end, the first end of the tubular connector being coupled ...


9
Rudolf F Bliem, Robert V Oakley, Van Taiariol: Apparatus for culturing animal cells. Baxter International, St Onge Steward Johnston & Reens, February 16, 1993: US05187095 (6 worldwide citation)

An apparatus for the in vitro culture of animal cells to recover secreted proteins of interest therefrom, affording the capability of being readily and predictably scaled up or down to desired protein production rates, comprised of a housed arrangement of culture subunits containing a packed bed of ...


10
Rudolf F Bliem, Robert V Oakley, Van C Taiariol: Method for culturing animal cells. Baxter International, St Onge Steward Johnston & Reens, April 7, 1992: US05102790 (2 worldwide citation)

A method of using an apparatus for the in vitro cultrue of animal cells to recover secreted proteins of interest therefrom, affording the capability of being readily and predictably scaled up or down to desired protein productin rates, comprised of a housed arrangement of culture subunits containing ...