1
Jason Christiansen, Robert Pinard, Maciej P Zerkowski, Gregory R Tedeschi: Method and system for standardizing microscope instruments. HistoRx, Gilberto M Villacorta, Foley & Lardner, March 15, 2011: US07907271 (7 worldwide citation)

Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be u ...


2
Robert Pinard, Gregory R Tedeschi, Christine Williams, Dongxiao Wang: Methods and system for validating sample images for quantitative immunoassays. HistoRx, Gilberto M Villacorta, Daniel R Shelton, Foley & Lardner, April 17, 2012: US08160348 (5 worldwide citation)

A method and system for automatically evaluating quality of a slide-mounted tissue sample includes receiving a digital image of a magnified portion of the slide-mounted tissue sample. At least one quantitative quality indicator is automatically determined for at least one of the samples, and the dig ...


3
Jason H Christiansen, Robert Pinard, Mark Gustavson, Brian Bourke, Dylan M Reilly, Gregory R Tedeschi: Compartment segregation by pixel characterization using image data clustering. Historx, Gilberto M Villacorta, Daniel R Shelton, Foley & Lardner, December 18, 2012: US08335360 (4 worldwide citation)

The present invention relates generally to improved methods of defining areas or compartments within which biomarker expression is detected and quantified. In particular, the present invention relates to automated methods for delineating marker-defined compartments objectively with minimal operator ...


4
Jason Christiansen, Robert Pinard, Mark Gustavson, Brian Bourke, Gregory R Tedeschi, Dylan M Reilly, Maciej P Zerkowski, Christine Williams, Dongxiao Wang: Reproducible quantification of biomarker expression. Novartis, Gilberto M Villacorta, Daniel R Shelton, Foley & Lardner, January 19, 2016: US09240043 (2 worldwide citation)

A method is described for the reproducible quantification of biomarker expression, including biomarker expression in a tissue sample. Methods and systems are described whereby reproducible scores for biomarker expression are obtained independent of instrument, its location, or operator.


5
Robert Pinard, Gregory R Tedeschi, Mark Gustavson: Method and system for determining an optimal dilution of a reagent. HistoRx, Gilberto M Villacorta, Daniel R Shelton, Foley & Lardner, February 21, 2012: US08121365 (1 worldwide citation)

A system and method for automatically and quantitatively determining the optimal dilution of a reagent is provided. In one embodiment of the claimed method, a plurality of dilution sets are received, where each of the dilution sets consist of a different respective dilution value and a respective pl ...


6
Robert Pinard, Gregory R Tedeschi, Christine Williams, Dongxiao Wang: Methods and system for validating sample images for quantitative immunoassays. HistoRx, Gilberto M Villacorta, Daniel R Shelton, Foley & Lardner, April 9, 2013: US08417015 (1 worldwide citation)

A method and system for automatically evaluating quality of a slide-mounted tissue sample includes receiving a digital image of a magnified portion of the slide-mounted tissue sample. At least one quantitative quality indicator is automatically determined for at least one of the samples, and the dig ...


7
Jason Christiansen, Robert Pinard, Maciej P Zerkowski, Gregory R Tedeschi: Method and system for standardizing microscope instruments. HistoRx, Gilberto M Villacorta, Daniel R Shelton, Foley & Lardner, November 20, 2012: US08314931 (1 worldwide citation)

Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be u ...


8
Joyce E Heckman, Robert Pinard, John M Burke: Method for placing a photo-cross-linking agent at specific internal sites within the sequence of synthetic strands of ribonucleic acids. The University of Vermont and State Agricultural College, Wolf Greenfield & Sacks P C, September 26, 2000: US06124099 (1 worldwide citation)

This invention describes novel photoactive ribonucleotides that contain photocrosslinking agents placed at specific internal positions within a ribonucleotide. The invention also provides methods for identifying novel, sequence-specific target molecules, using the photoactive ribonucleotides of the ...


9
Jason Christiansen, Robert Pinard, Maciej P Zerkowski, Gregory R Tedeschi: Method and system for standardizing microscope instruments. HistoRx, Gilberto M Villacorta, Daniel R Shelton, Foley & Lardner, April 23, 2013: US08427635 (1 worldwide citation)

Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be u ...


10
Jason H Christiansen, Robert Pinard, Mark Gustavson, Brian Bourke, Dylan M Reilly, Gregory R Tedeschi: Compartment segregation by pixel characterization using image data clustering. HistoRx, Gilberto M Villacorta, Daniel R Shelton, Foley & Lardner, February 18, 2014: US08655037

The present invention relates generally to improved methods of defining areas or compartments within which biomarker expression is detected and quantified. In particular, the present invention relates to automated methods for delineating marker-defined compartments objectively with minimal operator ...