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Stephen Thomas Davis, Scott Howard Dickerson, Philip Anthony Harris, Robert Neil Hunter III, Lee Frederick Kuyper, Karen Elizabeth Lackey, Michael Joseph Luzzio, James Marvin Veal, Duncan Herrick Walker: Substituted oxidole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors. SmithKline Beecham Corporation, John L Lemanowicz, April 9, 2002: US06369086 (39 worldwide citation)

The present invention relates generally to novel substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of protein kinase activated signalling pathways. In p ...


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Stephen Thomas Davis, Scott Howard Dickerson, Stephen Vernon Frye, Philip Anthony Harris, Robert Neil Hunter III, Lee Frederick Kuyper, Karen Elizabeth Lackey, Michael Joseph Luzzio, James Marvin Veal, Duncan Herrick Walker: Substituted oxindole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors and compositions and methods of treating chemotherapy and radiation therapy side effects. SmithKline Beecham Corporation, Jennifer L Fox, September 12, 2006: US07105529 (34 worldwide citation)

Compounds of formula (I): wherein X is N, CH, CCF3, or C(C1-12 aliphatic); R4 is sulfonic acid, C1-12 aliphatic-sulfonyl, sulfonyl-C1-12 aliphatic, C1-12 aliphatic-sulfonyl-C1-6 aliphatic, C1-6 aliphatic-amino, R7-sulfonyl, R7 sulfonyl-C1-12 aliphatic, R7-aminosulfonyl, R7-aminosulfonyl-C1-12 alipha ...


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Steven Thomas Dock, Andrew James Carpenter, Robert Neil Hunter III, Yulin Wu, Ved P Srivastava: Peptide YY analogs. GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT, Jason C Fedon, William T Han, September 13, 2016: US09441023

The present invention relates to novel analogs of PYY that have an improved therapeutic profile when compared to native human PYY. These novel PYY analogs are useful in the treatment of obesity, diabetes, and other disorders.


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David Harold Drewry, Robert Neil Hunter III: Chemical compounds. SmithKline Beecham Corporation, John L Lemanowicz, Kathryn L Coulter, February 12, 2008: US07329678

Benzimidazolyl-pyridine derivatives, which are useful as SGK-1 inhibitors are described herein. The described invention also includes methods of making such benzimidazolyl-pyridine derivatives as well as methods of using the same in the treatment of diseases mediated by inappropriate SGK-1 activity.


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