1
Richard Sackler, Paul Goldenheim, Robert Kaiko: Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level. Euroceltique, Steinberg Raskin & Davidson, December 26, 1995: US05478577 (261 worldwide citation)

Patients are treated with 24-hour oral sustained release opioid formulations which upon administration quickly release an effective portion of the opioid contained therein such that there is an initially more rapid opioid release so that the minimum effective analgesic concentration of the opioid ca ...


2
Richard Sackler, Robert Kaiko, Paul Goldenheim: Method of treating humans with opioid formulations having extended controlled release. Purdue Pharma, Davidson Davidson & Kappel, November 7, 2000: US06143322 (184 worldwide citation)

Solid controlled-release oral dosage forms comprising a therapeutically effective amount of an opioid analgesic or a salt thereof which provide an extended duration of pain relief of about 24 hours, have a dissolution rate in-vitro of the dosage form, when measured by the USP Paddle Method at 100 rp ...


3
Richard Sackler, Robert Kaiko, Paul Goldenheim: Method of treating humans with opioid formulations having extended controlled release. Purdue Pharma, Davidson Davidson & Kappel, June 22, 2010: US07740881 (2 worldwide citation)

Solid controlled-release oral dosage forms comprising a therapeutically effective amount of an opioid analgesic or a salt thereof which provide an extended duration of pain relief of about 24 hours, have a dissolution rate in-vitro of the dosage form, when measured by the USP Paddle Method at 100 rp ...


4
Richard Sackler, Paul Goldenheim, Robert Kaiko: Controlled-releasing opioid formulations for treating pain. Euro Celtique, CHEN WENQING, September 4, 1996: CN94192723

Patients are treated with 24-hour oral sustained release opioid formulations which, upon administration, provide an initially rapid opioid absorption such that the minimum effective analgesic concentration of the opioid is more quickly achieved. These sustained release opioid formulations include an ...


5
Richard Sackler, Robert Kaiko, Benjamin Oshlack, Richard Sackler, Robert Kaiko, Benjamin Oshlack: Opioid formulations having extended controlled release. Euroceltique, Euroceltique, CHEN WENQING, June 7, 1995: CN94107699

This invention relates to a solid controlled-release oral dosage forms comprising a therapeutically effective amount of an opioid analgesic or a salt thereof which provide an extended duration of pain relief of about 24 hours, have a dissolution rate in-vitro of the dosage form, when measured by the ...


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