1
Robert P Lenk, Anthony G Durning, Robert J Klimchak, Joel Portnoff, Michelle L Tomsho: Method for size separation of particles. The Liposome Company, Kenneth B Rubin, Rosanne Goodman, September 7, 1999: US05948441 (69 worldwide citation)

Tangential flow filtration is used in the size separation of particles, such as liposomes and lipid particles. These particles may be passed through a tangential flow filtration device of any pore size desired. Tangential flow filter systems of various pore sizes may be used sequentially to obtain p ...


2
Robert P Lenk, Michelle L Tomsho, Robert L Suddith, Robert J Klimchak: Prostaglandin-lipid formulations. The Liposome Company, Allen Bloom, Catherine L Kurtz, Ronald G Ort, January 21, 1992: US05082664 (17 worldwide citation)

A liposome composition and methods for making same are disclosed, such compositions comprise an arachidonic acid metabolite such as a prostaglandin, preferably prostaglandin E.sub.1, a lipid, and a drying protectant such as a saccharide. The liposomes may be loaded with prostaglandin passively, or u ...


3
Robert P Lenk, Michelle L Tomsho, Robert L Suddith, Robert J Klimchak: Prostaglandin-lipid formulations. The Liposome Company, Allen Bloom, Ronald G Ort, November 16, 1993: US05262168 (14 worldwide citation)

A liposome composition and methods for making same are disclosed, such compositions comprise an arachidonic acid metabolite such as a prostaglandin, preferably prostaglandin E.sub.1, a lipid, and a drying protectant such as a saccharide. The liposomes may be loaded with prostaglandin passively, or u ...


4
Robert P Lenk, Michelle L Tomsho, Robert L Suddith, Robert J Klimchak, Andrew S Janoff, Sharma R Minchey, Marc J Ostro: Therapeutic use of multilamellar liposomal prostaglandin formulations. The Liposome Company, Kenneth Rubin, Rosanne Goodman, July 20, 1999: US05925375 (8 worldwide citation)

This invention provides a multilamellar liposome containing an arachidonic acid metabolite, two or more lipid-containing bilayers and two or more aqueous compartments containing a release-inhibiting buffer. Preferred arachidonic acid metabolites are the prostaglandins, particularly PGE.sub.1. The li ...


5
Robert J Klimchak: Blood cell separation. Interferon Sciences, Irene J Frangos, Vincent P Pirri, May 17, 1988: US04744907 (4 worldwide citation)

Hydroxyalkyl celluloses are useful as sedimenting agents in the non-destructive separation of red and white blood cells. Intact WBC recovery is higher than with conventional methods. The white blood cells may be used in interferon production.


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