1
Brian Froehler, Robert J Jones: Oligonucleotides containing 5-propynyl pyrimidines. Gilead Sciences, Daryl D Muenchau, January 16, 1996: US05484908 (353 worldwide citation)

Oligonucleotides with enhanced hybridization binding possessing 5-propynyluracil and/or 5-propynylcytosine in place of uracil and cytosine, respectively. These oligonucleotides are useful in traditional hybridization assays for detection of a specific DNA sequence.


2
Michael E Landry, Larry T Khoo, Erik J Wagner, Charles R Forton, Robert J Jones: Spinal stabilization systems and methods. Abbott Spine, Beth A Vrioni, Michael L Woods, July 31, 2007: US07250052 (338 worldwide citation)

A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient. Bone fastener assemblies may be coupled to vertebrae. Each bone fastener assembly may include a bone fastener and a collar. Th ...


3
Erik J Wagner, Robert J Jones: System and method for stabilizing the human spine with a bone plate. Spinal Concepts, Conley Rose & Tayon PC, February 29, 2000: US06030389 (333 worldwide citation)

A spinal plate system and method for fixation of the human spine is provided. In an embodiment, the spinal fixation system includes a plate, a coupling member and a locking system for substantially locking the coupling member in a desired position. The plate preferably has a borehole that allows the ...


4

5
Brian Froehler, Rick Wagner, Mark Matteucci, Robert J Jones, Arnold J Gutierrez, Jeff Pudlo: Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines. Gilead Sciences, Daryl D Muenchau, July 8, 1997: US05645985 (299 worldwide citation)

Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capa ...


6
Brian Froehler, Rick Wagner, Mark Matteucci, Robert J Jones, Arnold J Gutierrez, Jeff Pudlo: Methods of using oligomers containing modified pyrimidines. Gilead Sciences, Daryl D Muenchau, November 3, 1998: US05830653 (295 worldwide citation)

Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capa ...


7
Mark Matteucci, Robert J Jones, John Munger: Modified internucleoside linkages having one nitrogen and two carbon atoms. Gilead Sciences, Daryl D Muenchau, January 21, 1997: US05596086 (269 worldwide citation)

Oligonucleotide analogs are disclosed wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by a backbone linkage resistant to nucleases. The modified oligonucleotides are capable of strong hybridization to target RNA or DNA. The oligomers of the invention may be used ...


8
Erik J Wagner, Vincent J Jannetty, Robert J Jones: Method and apparatus for spinal fixation. Spinal Concepts, Eric B Meyertons, Meyertons Hood Kivlin Kowert & Goetzel P C, September 2, 2003: US06613050 (257 worldwide citation)

A spinal fixation implant system for correction and fixation of the human spine to facilitate an anatomically correct fusion. The spinal fixation system may include a connector, a spinal rod, a spinal fixation component, a sleeve, and a fastener. The spinal fixation component preferably includes a f ...


9
Mark Matteucci, Robert J Jones, Kuei Ying Lin: Pyrimidine derivatives. Gilead Sciences, Max D Hensley, December 21, 1999: US06005096 (228 worldwide citation)

A compound having the structure ##STR1## wherein R.sup.1 is H or a linker group; R.sup.24 is independently halo or C.sub.1 -C.sub.2 haloalkyl;


10
Mark D Matteucci, Robert J Jones: Pyrimidine derivatives for labeled binding partners. Gilead Sciences, Max D Hensley, June 9, 1998: US05763588 (221 worldwide citation)

Compounds having particular interest as labels and various novel uses in diagnostics and therapeutics are provided which have structure (1) ##STR1## wherein R.sup.1 is a binding partner, a linker or H; a and b are 0 or 1, provided that the total of a and b is 0 or 1;