1
Robert J Debs: Expression of cloned genes in the lung by aerosol-and liposome-based delivery. The Regents of the University of California, Townsend and Townsend and Crew, May 26, 1998: US05756353 (67 worldwide citation)

Methods for the delivery of genes directly to the lungs are disclosed. Liposome-nucleic acid complexes are delivered via aerosol with the subsequent in viva expression of a protein encoded by the delivered gene. The invention provides a convenient method for treating pulmonary disorders, as well as ...


2
Robert J Debs, Ning Zhu: Methods and compositions for in vivo gene therapy. The Regents of the University of California, Townsend and Townsend and Crew, September 30, 2003: US06627615 (44 worldwide citation)

Novel methods and compositions are provided for introducing a gene capable of modulating the genotype and phenotype into two or more tissues following systemic administration. The gene can be introduced into a mammalian host by way of an expression vector either as naked DNA or associated with lipid ...


3
Robert J Debs, Alan B Montgomery, John E Conte, Jeffrey A Golden: Prophylaxis of pneumocystis carinii with aerosilized pentamidine. Regents of the University of California, Hana Dolezalova, November 15, 1994: US05364615 (12 worldwide citation)

A method of preventing clinically manifest Pneumocystis carinii pneumonia in immunocompromised humans is provided wherein an aerosol of pentamidine is administered to the patient in a manner which delivers the aerosol to the patient's alveoli. Also provided is a method of treating Pneumocystis carin ...


4
Robert J Debs, Alan B Montgomery, John E Conte, Jeffrey A Golden: Suppression of Pneumocystis carinii using aerosolized pentamidine treatment. The Regents of the University of California, Hana Dolezalova, November 22, 1994: US05366726 (10 worldwide citation)

A method of preventing clinically manifest Pneumocystis carinii pneumonia in immunocompromised humans is provided wherein an aerosol of pentamidine is administered to the patient in a manner which delivers the aerosol to the patient's alveoli. Also provided is a method of treating Pneumocystis carin ...


5
Robert J Debs, Ning Zhu: Mammalian transformation complex comprising a lipid carrier and DNA encoding CFTR. The Regents of the University of California, Townsend and Townsend and Crew, September 16, 2003: US06620795 (1 worldwide citation)

Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclosed. Lipid carrier-nucleic acid complexes or nucleic acid abre are prepared then delivered via aerosol or systemically to the lung abre or lung plus extrapulmonary tiss ...


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Robert J Debs, Ning Zhu: Methods and compositions for in vivo gene therapy. The Regents of the University of California, Townsend And Townsend And Crew, June 12, 2003: US20030109475-A1

Novel methods and compositions are provided for introducing a gene capable of modulating the genotype and phenotype into two or more tissues following systemic administration. The gene can be introduced into a mammalian host by way of an expression vector either as naked DNA or associated with lipid ...


8
Robert J Debs: Methods and compositions for nonviral gene delivery. Tracy J Dunn IP, May 30, 2002: US20020065213-A1

Methods and compositions are described for the efficient delivery and expression of recombinant polynucleotides in animal cells in vitro or in vivo. In particular, a comprehensive approach of non-viral gene delivery is provided that has been optimized with regards to the vectors delivered, maximizin ...