1
Robert G Webster, Nicolai V Kaverin: Influenza virus replicated in mammalian cell culture and vaccine production. St Jude Children&apos s Research Hospital, Sterne Kessler Goldstein & Fox P L L C, February 5, 2002: US06344354 (40 worldwide citation)

The invention provides replication of high growth influenza virus strains, derived from clinical isolates, in cultured mammalian cells by infecting the mammalian cells with the high growth strains to obtain infected cells, and culturing the cells while maintaining a trypsin concentration range of 0. ...


2
Harriet L Robinson, Ellen F Fynan, Robert G Webster: Immunization by inoculation of DNA transcription unit. University of Massachusetts Medical Center, St Jude Children s Research Hospital, Hamilton Brook Smith & Reynolds P C, July 1, 1997: US05643578 (38 worldwide citation)

This invention relates to a method of immunizing a vertebrate, comprising introducing into the vertebrate a DNA transcription unit which comprises DNA encoding a desired antigen or antigens. The uptake of the DNA transcription unit by a host vertebrate results in the expression of the desired antige ...


3
Brian R Murphy, Robert M Chanock, Robert G Webster, Virginia S Hinshaw: Human use of avian-human reassortants as vaccines for influenza A virus. St Jude Children s Research Hospital, John S Roberts Jr, November 12, 1985: US04552758 (35 worldwide citation)

A method of producing a live attenuated vaccine useful in humans which comprises producing an influenza A reassortant virus by gene exchange between an avian influenza virus parent and a human influenza virus parent and then excluding the internal genes (that code for non-surface viral proteins) of ...


4
Robert G Webster, Nicolai V Kaverin: Influenza virus replicated in mammalian cell culture and vaccine production. St Jude Children s Research Hospital, Sterne Kessler Goldstein & Fox P L L C, October 20, 1998: US05824536 (17 worldwide citation)

The invention provides replication of high growth influenza virus strains, derived from clinical isolates, in cultured mammalian cells by infecting the mammalian cells with the high growth strains to obtain infected cells, and culturing the cells while maintaining a trypsin concentration range of 0. ...


5
Harriet L Robinson, Ellen F Fynan, Robert G Webster, Shan Lu: Immunization by inoculation of DNA transcription unit. University of Massachusetts Medical Center, St Jude Children s Research Hospital, Fish & Richardson P C, January 11, 2005: US06841381 (7 worldwide citation)

This invention relates to a method of immunizing a vertebrate, comprising introducing into the vertebrate a DNA transcription unit which comprises DNA encoding a desired antigen or antigens. The uptake of the DNA transcription unit by a host vertebrate results in the expression of the desired antige ...


6
Peter Palese, Adolfo Garcia Sastre, Richard J Webby, Juergen A Richt, Robert G Webster, Kelly M Lager: Genetically engineered swine influenza virus and uses thereof. Mount Sinai School of Medicine, St Jude Children s Research Hospital, The United States of America represented by The Secretary of Agriculture, Jones Day, February 28, 2012: US08124101 (5 worldwide citation)

The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invention relates to attenuated swin ...


7
Peter Palese, Adolfo Garcia Sastre, Richard J Webby, Juergen A Richt, Robert G Webster, Kelly M Lager: Genetically engineered swine influenza virus and uses thereof. Icahn School of Medicine at Mount Sinai, St Jude Children s Research Hospital, The United States of America represented by the Secretary of Agriculture, Jones Day, April 7, 2015: US08999352 (2 worldwide citation)

The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invention relates to attenuated swin ...


8
Brian R Murphy, Robert M Chanock, Robert G Webster, Virginia S Hinshaw: Use in an animal host and precursors for vaccines utilizing avian-human reassortants to combat influenza A virus. St Jude Children s Research Hospital, John S Roberts Jr, November 12, 1985: US04552757 (2 worldwide citation)

A method of producing a vaccine useful in animals which comprises producing a reassortment by gene exchange from an avian influenza A virus parent and an animal influenza A virus parent and then selecting for the reassortant containing two animal surface antigen genes and six avian internal genes by ...


9
Erich Hoffmann, Aleksandr S Lipatov, Richard J Webby, Elena A Govorkova, Robert G Webster: Modified influenza virus for monitoring and improving vaccine efficiency. St Jude Children s Research Hospital, Fish & Richardson P C, January 18, 2011: US07871626 (2 worldwide citation)

The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by alt ...


10
Erich Hoffmann, Aleksandr S Lipatov, Richard J Webby, Elena A Govorkova, Robert G Webster: Modified influenza virus for monitoring and improving vaccine efficiency. St Jude Children s Research Hospital, Fish & Richardson P C, October 23, 2012: US08293247 (1 worldwide citation)

The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by alt ...



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