John W Parce, Robert F Zuk: Measuring with zero volume cell. Molecular Devices Corporation, Allegretti & Witcoff, March 27, 1990: US04911794 (415 worldwide citation)

Methods and apparatuses are described for determining the presence of an analyte in a sample suspected of containing the analyte. The method comprises contacting a concentrate of a determinable element capable of being detected by means of a semiconductive electrode with the electrode in the presenc ...

Axel F Brisken, John R McKenzie, Robert F Zuk, Menahem Nassi, Mark W Cowan, Paul D Corl: Therapeutic ultrasonic catheter for delivering a uniform energy dose. Pharmasonics, Townsend and Townsend and Crew, October 2, 2001: US06296619 (339 worldwide citation)

A method of treating a target region in a body lumen, said method comprising: directing a uniform dose of ultrasonic energy from an interior of the lumen radially outward over a treatment length of the lumen, wherein the dosage of ultrasonic energy received at any one point along the length varies b ...

Robert F Zuk, David J Litman: Immunochromatographic assay with support having bound "MIP" and second enzyme. Syva Company, Bertram I Rowland, March 6, 1984: US04435504 (174 worldwide citation)

Chromatographic immunoassay employing a specific binding pair member and a label conjugate which delineates a border whose distance from one end of the chromatograph relates to the amount of analyte present. By combining the label conjugate and sample in a solution and immunochromatographing the sol ...

Robert F Zuk, Ian Gibbons, Gerald L Rowley, Edwin F Ullman: Double antibody for enhanced sensitivity in immunoassay. Syva Company, Bertram I Rowland, July 28, 1981: US04281061 (173 worldwide citation)

Method and compositions are provided for performing homogeneous immunoassays. The method involves having a signal producing system, which provides a detectable signal, which system includes a macromolecular member. The determination of the analyte, which is a member of a specific binding pair consis ...

Robert F Zuk, Edward T Maggio: Label modified immunoassays. Syva Company, Bertram I Rowland, June 17, 1980: US04208479 (133 worldwide citation)

Methods and reagents are provided for immunoassays employing as reagents a labelled receptor, where the label is capable of providing a detectable signal, and modifying reagents, capable of modifying the signal obtained from the label. When ligand (ligand analog for monoepitopic ligands) is present ...

Robert F Zuk, Richard D Armenta, Jonathan Briggs: Migratory detection immunoassay. Molecular Devices Corporation, Allegretti & Witcoff, September 11, 1990: US04956275 (108 worldwide citation)

Novel methods and devices are provided for detecting analytes, where the sample is placed upstream from a reagent which is a component of a signal-producing system. The detection zone is provided upstream from the sample, where the amount of reagent which becomes bound at two sites is determined and ...

Robert F Zuk, Edwin F Ullman: Fluorescent scavenger particle immunoassay. Syva Company, Bertram I Rowland, March 17, 1981: US04256834 (102 worldwide citation)

Novel immunoassays are provided employing discrete particulate reagents for determining an analyte which is a member of a specific binding pair-ligand and homologous receptor. The assay employs as a first reagent, a member of said pair bound to an insoluble particle (particle conjugate); as a second ...

Robert F Zuk: Assay method for whole blood samples. Syntex, Theodore J Leitereg, June 10, 1986: US04594327 (96 worldwide citation)

Methods and compositions are provided for performing an assay on whole blood samples. The method is for a determination of an analyte which is a member of a specific binding pair (sbp) consisting of ligand and homologous receptor. The method involves a binding agent for the red blood cells in such s ...

Dennis R Gould, Robert F Zuk: Determination of analytes in particle-containing medium. Syntex, Bertram I Rowland, Theodore J Leitereg, November 12, 1985: US04552839 (76 worldwide citation)

Methods and compositions are provided for concentrating particles in a minute area on a solid surface. The method permits the detection of small amounts of analytes by providing for an observable signal in relation to the concentration of particles in the area.

Robert F Zuk, Sae Hyun Choo: Fluorescent labelling compositions and methods for their use. First Medical, Townsend and Townsend and Crew, July 22, 1997: US05650334 (65 worldwide citation)

A fluorescent labelling composition comprises a linear polysaccharide backbone molecule having a plurality of target-binding molecules, such as antibodies or nucleic acids, attached at spaced-apart intervals thereon. Each of the target-binding molecules, in turn, includes a multiplicity of fluoresce ...