1
Benjamin Oshlack, Mark Chasin, John J Minogue, Robert F Kaiko: Controlled release oxycodone compositions. Euro Celtigue, Steinberg Raskin & Davidson, April 16, 1996: US05508042 (300 worldwide citation)

A method for substantially reducing the range in daily dosages required to control pain in approximately 90% of patients is disclosed whereby an oral solid controlled release dosage formulation having from about 10 to about 40 mg of oxycodone or a salt thereof is administered to a patient. The formu ...


2
Benjamin Oshlack, Mark Chasin, John J Minogue, Robert F Kaiko: Controlled release oxycodone compositions. Euro Celtique, Steinberg Raskin & Davidson P C, August 27, 1996: US05549912 (270 worldwide citation)

A method for substantially reducing the range in daily dosages required to control pain in approximately 90% of patients is disclosed whereby an oral solid controlled release dosage formulation having from about 10 to about 40 mg of oxycodone or a salt thereof is administered to a patient. The formu ...


3
Richard S Sackler, Robert F Kaiko, Paul Goldenheim: Method of treating pain by administering 24 hour oral opioid formulations. Purdue Pharma, Steinberg Raskin & Davidson P C, September 30, 1997: US05672360 (244 worldwide citation)

Patients are treated with 24-hour oral sustained release opioid formulations which, upon administration, provide an initially rapid opioid absorption such that the minimum effective analgesic concentration of the opioid is more quickly achieved. These sustained release opioid formulations include an ...


4
Philip J Palermo, Robert D Colucci, Robert F Kaiko: Method of preventing abuse of opioid dosage forms. Euro Celtique, Davidson Davidson & Kappel, May 8, 2001: US06228863 (242 worldwide citation)

The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist is combined with an opioid antagonist into an oral dosage form which would require at least a two-step ...


5
Robert F Kaiko, Robert D Colucci: Opioid agonist/opioid antagonist/acetaminophen combinations. Euro Celtique, Davidson Davidson & Kappel, April 23, 2002: US06375957 (237 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an opioid agonist, acetaminophen and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the ...


6
Robert F Kaiko, Robert D Colucci: Opioid agonist/antagonist combinations. Euro Celtique, Davidson Davidson & Kappel, February 24, 2004: US06696066 (166 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is ana ...


7
Philip J Palermo, Robert F Kaiko, Robert D Colucci: Method of preventing abuse of opioid dosage forms. Euro Celtique, Davidson Davidson & Kappel, September 30, 2003: US06627635 (150 worldwide citation)

The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist is combined with an opioid antagonist into an oral dosage form which would require at least a two-step ...


8
Robert F Kaiko, Robert D Colucci: Opioid agonist/antagonist combinations. Euro Celtique, Davidson Davidson & Kappell, August 21, 2001: US06277384 (144 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is ana ...


9
Robert F Kaiko, Robert D Colucci: Opioid agonist/antagonist combinations. Euro Celtique, Davidson Davidson & Kappel, November 5, 2002: US06475494 (128 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is ana ...


10
Robert F Reder, Paul D Goldenheim, Robert F Kaiko: Method of providing sustained analgesia with buprenorphine. Euro Celtique, Davidson Davidson & Kappel, October 19, 1999: US05968547 (108 worldwide citation)

A method of effectively treating pain in humans is achieved by administering buprenorphine in accordance with first order kinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained, and thereafter maintaining the a ...