1
Robert E Richard: Cross-linked polymer particles. Boston Scientific Scimed, Bingham McCutchen, April 9, 2013: US08414927 (37 worldwide citation)

Biodegradable cross-linked particles, as well as related compositions and methods, are disclosed.


2
Robert E Richard: Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent. Boston Scientific Scimed, Mayer & Williams PC, Keum J Park Esq, David B Bonham Esq, June 3, 2008: US07381418 (35 worldwide citation)

An implantable or insertable medical device which comprises (a) a therapeutic agent and (b) a polymeric release region that controls the release of the therapeutic agent upon administration to a patient. The polymeric release region comprises a radiation-crosslinked polymer, and the polymeric releas ...


3
Robert E Richard, Frederick H Strickler, Marlene C Schwarz, Rudolf Faust, Shrirang V Ranade, Michael N Helmus: Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility. Boston Scientific Scimed, Mayer & Williams PC, David B Bonham, September 17, 2013: US08535702 (32 worldwide citation)

The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least ...


4
Robert E Richard: Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent. Boston Scientific Scimed, Mayer & Williams PC, David B Bonham Esq, July 10, 2007: US07241455 (31 worldwide citation)

An implantable or insertable medical device which comprises (a) a therapeutic agent and (b) a polymeric release region that controls the release of the therapeutic agent upon administration to a patient. The polymeric release region comprises a radiation-crosslinked polymer, and the polymeric releas ...


5
Maria Palasis, Wendy Naimark, Robert E Richard: Medical devices for delivery of therapeutic agents. Boston Scientific Scimed, Mayer & Williams PC, David B Bonham Esq, Keum J Park Esq, February 17, 2009: US07491234 (31 worldwide citation)

The present invention is generally directed to medical devices, and more specifically to medical devices that are at least partially insertable or implantable into the body of a patient. The medical devices generally comprise (a) a therapeutic agent, more typically, a high-molecular-weight therapeut ...


6
Marlene C Schwarz, Robert E Richard: Multiphase polymeric drug release region. Boston Scientific Scimed, Mayer & Williams PC, David B Bonham, Keum J Park, May 10, 2011: US07939094 (18 worldwide citation)

A method is provided for modulating the rate of release of a therapeutic agent from a release region, which constitutes at least a portion of an implantable or insertable medical device and which controls the rate at which the therapeutic is released from the medical device. The method comprises: (a ...


7
Robert E Richard: Controlled degradation materials for therapeutic agent delivery. Boston ScientificScimed, Mayer & Williams PC, David B Bonham, April 14, 2009: US07517914 (18 worldwide citation)

According to an aspect of the present invention, polymeric release regions are provided, which contain one or more partially biodegradable progenitor polymers and which control the release of one or more therapeutic agents disposed beneath or within the same. The progenitor polymers within the relea ...


8
Robert E Richard: Polymer-filler composites for controlled delivery of therapeutic agents from medical articles. Boston Scientific Scimed, Mayer & Williams PC, David B Bonham, May 26, 2009: US07537781 (12 worldwide citation)

A medical article comprising: (a) a therapeutic agent; and (b) a release region comprising (i) a polymer and (ii) a filler comprising inorganic platelet particles. Upon placement of such a medical article at a position on or within a patient, the release region regulates the rate of release of the t ...


9
Frederick H Strickler, Robert E Richard: Medical devices containing radiation resistant block copolymer. Boston Scientific Scimed, Mayer & Williams PC, David B Bonham, Keum J Park, May 11, 2010: US07713539 (12 worldwide citation)

The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant block copolymer materials for use in connection with insertable or implantable medical devices. Th ...


10
Robert E Richard, Frederick H Strickler: Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents. Boston Scientific Scimed, Mayer & Williams PC, David B Bonham Esq, Keum J Park Esq, April 15, 2008: US07357940 (10 worldwide citation)

Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region that controls the release of the therapeutic agent upon administration to a patient. The polymer release region comprises a graft copolymer, which further ...