1
Philip J Palermo, Robert D Colucci, Robert F Kaiko: Method of preventing abuse of opioid dosage forms. Euro Celtique, Davidson Davidson & Kappel, May 8, 2001: US06228863 (236 worldwide citation)

The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist is combined with an opioid antagonist into an oral dosage form which would require at least a two-step ...


2
Robert F Kaiko, Robert D Colucci: Opioid agonist/opioid antagonist/acetaminophen combinations. Euro Celtique, Davidson Davidson & Kappel, April 23, 2002: US06375957 (233 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an opioid agonist, acetaminophen and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the ...


3
Robert F Kaiko, Robert D Colucci: Opioid agonist/antagonist combinations. Euro Celtique, Davidson Davidson & Kappel, February 24, 2004: US06696066 (163 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is ana ...


4
Philip J Palermo, Robert F Kaiko, Robert D Colucci: Method of preventing abuse of opioid dosage forms. Euro Celtique, Davidson Davidson & Kappel, September 30, 2003: US06627635 (146 worldwide citation)

The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist is combined with an opioid antagonist into an oral dosage form which would require at least a two-step ...


5
Robert F Kaiko, Robert D Colucci: Opioid agonist/antagonist combinations. Euro Celtique, Davidson Davidson & Kappell, August 21, 2001: US06277384 (141 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is ana ...


6
Robert F Kaiko, Robert D Colucci: Opioid agonist/antagonist combinations. Euro Celtique, Davidson Davidson & Kappel, November 5, 2002: US06475494 (125 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is ana ...


7
Robert F Kaiko, Robert D Colucci: Opioid agonist / antagonist combinations. Purdue Pharma, Davidson Davidson & Kappel, February 6, 2007: US07172767 (99 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is ana ...


8
Robert F Kaiko, Robert D Colucci: Opioid agonist/antagonist combinations. Purdue Pharma, Davidson Davidson & Kappel, September 2, 2008: US07419686 (59 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is ana ...


9
Robert F Kaiko, Robert D Colucci: Opioid agonist/antagonist combinations. Purdue Pharma, Davidson Davidson & Kappel, July 6, 2010: US07749542 (37 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is ana ...


10
Robert F Kaiko, Robert D Colucci: Opioid agonist/antagonist combinations. Purdue Pharma, Davidson Davidson & Kappel, January 31, 2012: US08105631 (36 worldwide citation)

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is ana ...