1
Ashok R Amin, Steven B Abramson, Lorne M Golub, Nungavaram S Ramamurthy, Thomas F McNamara, Robert A Greenwald, Howard Trachtman: Method of using tetracycline compounds for inhibition of endogenous nitric oxide production. The Research Foundation of State University of New York, Hospital for Joint Diseases, Hoffmann & Baron, August 4, 1998: US05789395 (107 worldwide citation)

A method is disclosed for inhibiting endogenous production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo mammalian system. The method employs a tetracycline compound to inhibit production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase ( ...


2
Waldemar Pruzanski, Lorne M Golub, Peter Vadas, Robert A Greenwald, Nangavarum S Ramamurthy, Thomas F McNamara: Inhibition of excessive phospholipase A.sub.2 activity and/or production by non-antimicrobial tetracyclines. The Research Foundation of State Univ of New York, Hoffman & Baron, March 28, 2000: US06043231 (68 worldwide citation)

A method for treating mammals suffering from conditions associated with excess phospholipase A.sub.2 activity and/or production comprising administering to the mammal an effective amount of a non-antimicrobial tetracycline sufficient to inhibit excess phospholipase A.sub.2 activity and/or production ...


3
Lorne M Golub, Nangavarum S Ramamurthy, Thomas F McNamara, Robert A Greenwald, Tsutomu Kawai, Takashi Hamasaki, Michiya Shimamura, Goro Kobayashi, Tetsuo Takigawa, Hisashi Iwata: Method to reduce connective tissue destruction. Kuraray, Hoffmann & Baron, November 2, 1993: US05258371 (62 worldwide citation)

Provided is a method of treating humans or animals suffering from a condition or disease characterized by excessive collagen destruction, which comprises administering to said human or animal an effective amount of a 12a-deoxytetracycline represented by the following general formula ##STR1## The met ...


4
Lorne M Golub, Nangavarum S Ramamurthy, Thomas F McNamara, Robert A Greenwald: Composition comprising indomethacin [non-steroidal anti-inflammatory agent] and effectively non-antibacterial tetracycline to reduce bone loss. The Research Foundation of State University of New York, Hoffmann & Baron, October 17, 1995: US05459135 (52 worldwide citation)

A method for treating mammals suffering from rheumatoid arthritis and other tissue-destructive (chronic inflammatory or other) conditions associated with excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti-metalloproteinase, b ...


5
Waldemar Pruzanski, Lorne M Golub, Peter Vadas, Robert A Greenwald, Nangavarum S Ramamurthy, Thomas F McNamara: Inhibition of excessive phospholipase A.sub.2 activity and/or production by non-antimicrobial tetracyclines. The Research Foundation of State University of New York, Hoffmann & Baron, June 4, 1996: US05523297 (52 worldwide citation)

A method for treating mammals suffering from conditions associated with excess phospholipase A.sub.2 activity and/or production comprising administering to the mammal an effective amount of a non-antimicrobial tetracycline sufficient to inhibit excess phospholipase A.sub.2 activity and/or production ...


6
Lorne M Golub, Nangavarum S Ramamurthy, Thomas F McNamara, Robert A Greenwald: Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline. The Research Foundation of State University of New York, Hoffmann & Baron, May 3, 1994: US05308839 (51 worldwide citation)

A method for treating mammals suffering from rheumatoid arthritis, other tissue-destructive conditions, and chronic inflammatory or other conditions associated with excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti-metallopr ...


7
Ashok R Amin, Steven B Abramson, Lorne M Golub, Nungavaram S Ramamurthy, Thomas F McNamara, Robert A Greenwald, Howard Trachtman: Method for inhibiting expression of inducible nitric oxide synthase with tetracycline. The Research Foundation of The State University of New York, Hospital For Joint Diseases, Hoffmann & Baron, July 6, 1999: US05919775 (48 worldwide citation)

The invention is a method of inhibiting the production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo biological system. The method employs a tetracycline compound to inhibit the production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase ...


8
Lorne M Golub, Nangavarum S Ramamurthy, Thomas F McNamara, Robert A Greenwald: Composition comprising fluriprofen and effectively non-antibacterial tetracycline to reduce bone loss. The Research Foundation of State University of New York, Hoffmann & Baron, June 14, 1994: US05321017 (46 worldwide citation)

A method for treating mammals suffering from rheumatoid arthritis and other tissue-destructive (chronic inflammatory or other) conditions associated with excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti-metalloproteinase, b ...


9
Lorne M Golub, Christopher T Ritchlin, Robert A Greenwald, Sally Haas Smith, Susan A Moak, Hsi Ming Lee: Method of using tetracycline compounds to enhance interleukin-10 production. The Research Foundation of State University of New York, University of Rochester, Hoffmann & Baron, January 18, 2000: US06015804 (43 worldwide citation)

The invention is a method of enhancing endogenous interleukin-10 production in mammalian cells and tissues, which includes administering an effective amount of a tetracycline derivative. The method also includes enhancing interleukin-10 production by administering an effective amount of the tetracyc ...


10
Bruce Schneider, Robert A Greenwald, Jonathan Maimon, Kenneth Gorray, Lorne M Golub, Thomas F McNamara, Nangavarum S Ramamurthy: Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines. The Research Foundation of State University of New York, Hoffmann & Baron, September 3, 1991: US05045538 (43 worldwide citation)

A method for treating mammals suffering from skeletal muscle wasting and/or intracellular protein degradation of skeletal muscle systems by administering to the mammal an amount of tetracycline which results in a significant reduction of the muscle wasting and protein degradation is disclosed. In ad ...