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Richard Sackler: Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant. Davidson Davidson & Kappel, April 10, 2003: US20030068392-A1

Disclosed in certain embodiments is an oral dosage form comprising: a therapeutically effective amount of an opioid analgesic; an opioid antagonist; and an irritant in an effective amount to impart an irritating sensation to an abuser upon administration of the dosage form after tampering.


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Paul Goldenhim, Peter Lacouture, Donna Donigi Gale, Mark Chasin, Richard Sackler: Prolonged anesthesia in joints and body spaces. Davidson Davidson & Kappel, September 18, 2003: US20030175357-A1

Sustained release local anesthetic formulations are administered intra articularly and/or into body spaces/cavities. The formulation is preferably a plurality of injectable microparticles including a local anesthetic and an effective amount of a biocompatible, biodegradable, sustained release materi ...


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Mark Alfonso, Paul Goldenheim, Richard Sackler: Formulation for respiratory tract administration. Davidson Davidson & Kappel, February 21, 2002: US20020022663-A1

A dosage form for intranasal and/or inhalation administration of an analgesic having low opioid receptor binding activity to a warm blooded animal, that includes a pharmaceutically effective amount of the analgesic. A preferred analgesic is tramadol, a tramadol and/or a pharmaceutically acceptable s ...


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Paul Goldenheim, Peter Lacouture, Donna Donigi Gale, Mark Chasin, Richard Sackler: Prolonged anesthesia in joints and body spaces. Davidson Davidson & Kappel, May 9, 2002: US20020054915-A1

Sustained release local anesthetic formulations are administered intra articularly and/or into body spaces/cavities. The formulation is preferably a plurality of injectable microparticles including a local anesthetic and an effective amount of a biocompatible, biodegradable, sustained release materi ...


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Richard SACKLER: Pharmaceutical formulation containing irritant. Purdue Pharma, Davidson Davidson & Kappel, October 14, 2010: US20100261713-A1

Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse; and an effective amount of an irritant to impart an irritating sensation to an abuser upon administration of said dosage form after tampering.


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Richard Sackler: Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant agent. Purdue Pharma, August 9, 2012: US20120201761-A1

Disclosed in certain embodiments is an oral dosage form comprising: a therapeutically effective amount of an opioid analgesic; an opioid antagonist; andan irritant in an effective amount to impart an irritating sensation to an abuser upon administration of the dosage form after tampering.


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