1
Richard Sackler, Paul Goldenheim, Robert Kaiko: Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level. Euroceltique, Steinberg Raskin & Davidson, December 26, 1995: US05478577 (261 worldwide citation)

Patients are treated with 24-hour oral sustained release opioid formulations which upon administration quickly release an effective portion of the opioid contained therein such that there is an initially more rapid opioid release so that the minimum effective analgesic concentration of the opioid ca ...


2
Richard Sackler, Robert Kaiko, Paul Goldenheim: Method of treating humans with opioid formulations having extended controlled release. Purdue Pharma, Davidson Davidson & Kappel, November 7, 2000: US06143322 (184 worldwide citation)

Solid controlled-release oral dosage forms comprising a therapeutically effective amount of an opioid analgesic or a salt thereof which provide an extended duration of pain relief of about 24 hours, have a dissolution rate in-vitro of the dosage form, when measured by the USP Paddle Method at 100 rp ...


3
Richard Sackler, Paul Goldenheim, Mark Chasin: Prolonged local anesthesia with colchicine. Euro Celtique, Steinberg Raskin & Davidson P C, May 5, 1998: US05747060 (183 worldwide citation)

A formulation for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a revers ...


4
Mark Chasin, Richard Sackler, Ronald M Burch, Paul Goldenheim, Joseph Tigner: Formulations and methods for providing prolonged local anesthesia. Euro Celtique, Davidson Davidson & Kappel, August 24, 1999: US05942241 (156 worldwide citation)

A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obt ...


5
Paul Goldenheim, Mark Chasin, Richard Sackler, Ronald M Burch, Joseph Tigner: Formulations and methods for providing prolonged local anesthesia. Euro Celtique, Davidson Davidson & Kappel, February 25, 2003: US06524607 (154 worldwide citation)

A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obt ...


6
Paul Goldenheim, Donna Donigi Gale, Richard Sackler, Peter Lacouture, Mark Chasin: Prolonged anesthesia in joints and body spaces. Euro Celtique, Davidson Davidson & Kappel, March 18, 2003: US06534081 (140 worldwide citation)

Sustained release local anesthetic formulations are administered intra articularly and/or into body spaces/cavities. The formulation is preferably a plurality of injectable microparticles including a local anesthetic and an effective amount of a biocompatible, biodegradable, sustained release materi ...


7
Richard Sackler: Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant. Purdue Pharma, Davidson Davidson & Kappel, February 19, 2008: US07332182 (119 worldwide citation)

Disclosed in certain embodiments is an oral dosage form comprising: a therapeutically effective amount of an opioid analgesic; an opioid antagonist; and an irritant in an effective amount to impart an irritating sensation to an abuser upon administration of the dosage form after tampering.


8
Mark Chasin, Paul Goldenheim, Richard Sackler, Joseph Tigner, Ronald M Burch: Formulations and methods for providing prolonged local anesthesia. Euro Celtique, Davidson Davidson & Kappel, July 26, 2005: US06921541 (105 worldwide citation)

A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obt ...


9
Paul Goldenheim, Peter Lacouture, Donna Donigi Gale, Mark Chasin, Richard Sackler: Prolonged anesthesia in joints and body spaces. Euro Celtique, Davidson Davidson & Kappel, June 19, 2001: US06248345 (100 worldwide citation)

Sustained release local anesthetic formulations are administered intra articularly and/or into body spaces/cavities. The formulation is preferably a plurality of injectable microparticles including a local anesthetic and an effective amount of a biocompatible, biodegradable, sustained release materi ...


10
Richard Sackler: Pharmaceutical formulation containing irritant. Euro Celtique, Philip C Strassburger, Alan L Koller, January 2, 2007: US07157103 (99 worldwide citation)

Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse; and an effective amount of an irritant to impart an irritating sensation to an abuser upon administration of said dosage form after tampering.